The Clinical Study of Non-ST-segment Elevation ACS after PCI in Patients Applying the Method Clearing Heat and Toxic Material
|School||Shandong University of Traditional Chinese Medicine|
|Course||Chinese medical science|
|Keywords||heat-clearing and detoxicating NSTE-ACS vascular endothelial growthfactor placenta growth factor high-sensitivity C-reactive protein|
Objective: To observe the clinical efficacy and influence of blood-related indicatorsabout treating non-ST-segment elevation ACS after PCI in patients applying the Methodclearing heat and toxic material, Explore the mechanism about the effect of the Methodclearing heat and toxic material on treating non-ST-segment elevation ACS after PCI inpatients and provide a theoretical basis and clinical evidence for tradition chinesemedicine curing non-ST-segment elevation ACS. Methods:60patients of ACS withToxic-heat and blood-stisis syndromes accompany PCI.they were divided randomly intotwo groups.30patients (control group)applied conventional western medicine therapy and30patients (test group) were dosed heat-clearing and detoxicating partyrespectively.Respectively observed the onset of cardiovascular events, the TCM clinicalsymptoms and tonguepulse. The concentration of vascular endothelial growth factor(VEGF), placental growth factor (PLGF), ultra-sensitivity C-reactive protein (Hs-CRP),lipids and so on were measured before PCI and after the first day, the fifth day, the fourthweek the method of enzyme linked immunosorbent assay (ELISA).Results: The totaleffective rate of relieving angina66.67%(P<0.05),Nitroglycerin efficient66.33%(P<0.05),improving ECG60.00%(P<0.05)and meliorating symptoms60.70%(P<0.05)in the controlgroup. The total effective rate of relieving angina and nitroglycerin90.00%(P<0.01),Nitroglycerin efficient86.67%(P<0.01)、improving ECG83.33(P<0.01)and melioratingsymptoms86.66%(P<0.05)in the test group were significantly better than those of thecontrol group. The level of TC、LDL-C、TG were decreased in the test group(P<0.05).the level of HDL-C were no significant difference in the test group(P<0.05). Test group serumVEGF levels significantly higher than that before treatment, better than the control group(P<0.01). Test group on the placental growth factor and ultra-sensitivity C-reactiveprotein levels drop of better than in the control group(P<0.01).Conclusion: Theconventional Western medicine treatment plus Ningxin detoxification party can enhancethe efficacy of the ACS and reduce coronary events after PCI, they also own the moresafety and tolerance. Compared with Western medicine treatment only, they are more goodat pure the NSTE-ACS patients. The reason may be due to restraining the inflammationreaction and preserving the function of vessel endothelium.