Clinical observation of Tonifying the kidney and promoting blood circulation treatment of anovulatory infertility
|School||Beijing University of Traditional Chinese Medicine|
|Keywords||Tonifying the kidney and promoting blood circulation clomiphene Anovulatory infertility|
ObjectivesInfertility refers to the couple not contraception, with normal sexual life, living together for2years without a pregnancy. Among them, never happened pregnancy were known as primary infertility, had pregnancy and infertility is called secondary infertility. In recent years, with the rapid development of science and technology of water, the improvement of human life, human living environment changes, the incidence of infertility is the basic trend of increase year by year. The cause of infertility causes complex, single cause can be pathogenic, but the occurrence of infertility is often involved in many factors and long time effect. Anovulatory infertility has play a decisive role position in the various factors of infertility, in recent years the incidence has been increasing year after year trend. At present the treatment of anovulatory infertility by traditional Chinese medicine and Western medicine have achieved certain effect. Modern medicine for the treatment mainly focused on the use of appropriate drugs to induce ovulation, but because of the short-term and long-term side effects in the clinical application and curative effect is limited. Traditional Chinese medicine considers that the kidney deficiency disease machine is anovulatory infertility, which mingled with the stagnation of liver qi, blood stasis, phlegm and other causes, therefore, treatment of anovulatory infertility with TCM from invigorating the kidney. In this study, patients with Bushenhuoxue herbs on anovulatory infertility drug intervention, and at the same time with oral clomiphene citrate related control study, intends to explore the clinical effect and mechanism of therapeutic effect of Bushenhuoxue herbs on anovulatory infertility, to provide a new therapeutic method for the treatment of anovulatory infertility of traditional Chinese medicine, for the clinical treatment of the disease provide a clinical basis.Methods(1) according to the diagnostic criteria of traditional medicine and modern medicine on anovulatory infertility, at the same time, according to the study and formulate the inclusion criteria, exclusion criteria,60cases of ovulation in patients with anovulatory infertility clinical;(2)60anovulatory infertility patients were randomly divided into two groups,30patients in treatment group,30cases in the control group.(3) the treatment group oral Bushenhuoxue follicle, the pharmaceutical composition:dodder15g, root15g, medlar15g, Spatholobus15g, Ligustrum lucidum LOg, Eupatorium15g, pollen Typhae, angelica, Achyranthes bidentata LOg LOg15g. The specific method is:take with the menstrual cycle of fifth days or fifth days of treatment with progesterone withdrawal vaginal bleeding started taking, conventional frying method, daily1agent, water morning and evening wear, serving a total of14days. The observation group was treated with clomiphene citrate, on the fifth day of menstrual cycle or progesterone withdrawal vaginal bleeding after treatment began to take fifth days,50mg/d, taking a total of5days.(4) the treatment group and the control group before and after treatment in patients with anovulatory infertility ovulation rate, pregnancy rate, the dominant follicle diameter size, endometrial thickness, serum sex hormone levels (E2, FSH, LH, PRL, P, T) were measured before and after treatment, at the same time statistics within group and between group. Comparative analysis.(5) the treatment group and the control group before and after treatment in patients with anovulatory infertility change TCM syndrome points to determine the efficacy of standard chinese.(6) statistical method:all data input OFFICE EXCEL, and the formation of electronic databases, statistical data analysis using SPSS20statistical software, the measurement data with the mean standard deviation (X±S) representation, compared with the t test, count data using chi square test.Results(1) the clinical curative effect analysis:30cases of patients,15cases were cured,12cases markedly effective,8cases, invalid5cases, the cure rate was50%, markedly effective rate of40%, efficiency of26.77%, no efficiency of16.67%, the total effective rate of treatment group83.33%.30cases of control group of patients,10cases were cured,8cases markedly effective,5cases, invalid7cases, the cure rate was33.33%, markedly effective rate of26.67%, efficiency of16.67%, no efficiency23.33%, total effective rate of the control group76.67%.(2) a comparative analysis of the TCM syndrome integral:the treatment group and the control group before and after treatment to compare the group, found that the TCM syndrome integral of the two groups after treatment than before treatment were significantly lower, the difference was statistically significant (P<0.05). Treatment group and control group after treatment were compared between groups, TCM syndrome score in treatment group was significantly lower than the control group, the difference was statistically significant (P<0.05). The statistical results show that, the treatment group and the control group in symptom improvement have certain effect, but the treatment group in improving the TCM syndrome than the control group obviously.(3) a comparative analysis of the ovulation rate:30cases in the treatment group the ovulation rate was68.35%; the control group of30cases of ovulation rate was66.67%, the treatment group and the control group for comparison between groups, statistical analysis showed no difference between two groups (P>0.05P=0.742).(4) the pregnancy rate of comparative analysis:the treatment group of30cases pregnancy rate was60%; the control group of30cases pregnancy rate was36.67%, the treatment group and the control group for comparison between groups, the statistical analysis indicated that there were significant differences in P=0.042between the two groups (P<0.05).(5) the dominant follicle diameter comparative analysis:30cases in the treatment group after treatment than before treatment the dominant follicle diameter increased significantly (P<0.05); the control group of30patients after the treatment of the dominant follicle diameter than before treatment were significantly increased, the difference was significant (P<0.05). The dominant follicle diameter after treatment was compared between groups, treatment group than in the control group with large diameter, but it was no statistical significance (P>0.05).(6) a comparative analysis of the endometrial thickness:30cases of endometrial thickness after treatment than before treatment thick treatment group, the difference was statistically significant (P<0.05);30cases of the control group after treatment than before treatment in endometrial thickness thickness, but the difference was not statistically significant (P>0.05). The statistical analysis and comparison of the two groups after treatment of endometrial thickness increases, the treatment group than the control group, the difference was significant (P<0.05).(7) comparative analysis to detect hormone levels:30cases in the treatment group were FSH, LH, T after treatment were decreased, but no significant difference (P>0.05); E2treatment E2increased, there was significant difference (P<0.05);30cases in the control group FSH, LH, E2after treatment than before treatment, hormone levels increased slightly, but no significant difference (P>0.05); T before and after treatment were not significantly different (P>0.05). The statistical results show that, treatment group had regulatory effect on FSH, LH and the ratio of E2, P, increased, decreased T; control group of FSH, LH increased, E2, T had no effect.(8) the basal body temperature (BBT) comparative analysis of measurement:the treatment group of30cases of basal body temperature recovery rate was76.67%, control group30cases of basal body temperature recovery rate was73.33%, the treatment group and the control group for comparison between groups, statistical analysis revealed no significant difference between the two groups (P>0.05).Conclusions The incidence of infertility is the basic trend increased year by year, anovulatory infertility accounted for the position in the whole play a decisive role in the occurrence of infertility. However, western medicine of ovulation induction therapy does have some limitations and side effects, but the treatment of traditional Chinese medicine has the advantages and characteristics of a certain, this study intervention on ovulation in patients with anovulatory infertility through the application of Bushen Huoxue herbs treatment group before and after treatment, the ovulation rate, pregnancy rate, the dominant follicle diameter size, endometrial thickness and the female sex hormone levels of six compared with the control group found in the above aspects have certain curative effect, especially in the induction of ovulation can increase the thickness of the endometrium, the follicle development and endometrial growth shows a synchronization, this is tantamount to improve endometrial receptivity increased greatly in ovulation period, in order to improve the ovulation rate also further improve the pregnancy rate, and reduce the pregnancy loss rates, which makes the majority of infertility patients to further meet the demands. Study on treatment of Bushen Huoxue legislation has confirmed that Chinese medicine can be applied in clinic, this study provides evidence for this conclusion certain.