Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Arrhythmia > Atrial fibrillation and atrial flutter

Analysis of the Pathogeny and Heart Rate Variability of Persistent Atrial Fibirllation

Author MaRuFei
Tutor GuanLin
School Shandong University of Traditional Chinese Medicine
Course Medical Imaging and Nuclear Medicine
Keywords persistent atrial fibrillation pathogeny heart rate vatiability the averagevalue of heart rate Long R-R interval
CLC R541.75
Type Master's thesis
Year 2013
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Objective:To determine the pathogenic factors of persistent atrial fibrillation(Af)from the aspects of pathogeny and the function of autonomic nerves,and to provideprevention and cure of Af with the theoretical supports.Methods:1.Retrospectivelyanalyzed the clinical data of116cases of patients with persistent Af.2.Analyzed therelationship between the time domain indexes with the length (L) and dispersion (D) ofscattergram of30healthy controls.3.Compared the form and related data of scattergram,theaverage value of heart rate during daytime and night,long R-R interval in Af group(30cases of patients with persistent Af who had results of dynamic ECG detection) with that inthe control group.Result:1.In116cases of patients with persistent Af,the advanced ageaccounted for62.07%,the main pathogeny was hypertension(59.48%),coronary heartdisease(40.52%),diabetes(25.00%),rheumatic heart disease(12.93%),and pulmonary heartdisease(6.90%).2.L correlated well with SDNN and HRV triangle index(P<0.01),Dcorrelated well with RMSSD and PNN50(P<0.01).3.Scattergram showed that all ofcontrols were comet shape as well as most of patients with persistent Af weresector.Compared with the control group,dispersion and piecewise dispersion of Af groupincreased obviously,and the difference was significant(P<0.01).4.In the two groups,theaverage value of heart rate during daytime was higher than the night.5.During24h,mostpatients of Af group had long R-R interval, times of long R-R interval during the nightwere significantly more than the daytime,nobody of the control group had long R-Rinterval.Conclusion:1.Advanced age,hypertension,Coronary heart disease,diabetes, rheumatic heart disease,pulmonary heart disease and imbalance of the automomic nervoussystem were the pathogenic factors of persistent Af.2.Autonomic nerves of patients withpersistent Af damaged,mainly the vagus nerve tension increased.2.Circadian rhythmchanges of heart rate caused by autonomic nerves were similar in the two groups,theaverage value of heart rate during daytime was higher than the night.3.The extendedrefractory period of the atrioventricular node caused by the increased vagus tension wasthe reason of long R-R interval.4.Prevention of persistent Af mainly depends on activeprevention and treatment of the primary disease.Control of circadian rhythm and regulationof neural equilibrium may become the new directions in prevention and treatment of Af.

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