The Effects of Smoking on the Antihypertensive Efficacy, Inflammatory Factors and Arterial Stiffness of Amlodipine
|School||Central South University|
|Keywords||Smoking Hypertension Monocyte chemoattractantprotein-1 High-sensitivity C-reactive protein Adiponectin Brachial-ankle pulse wave velocity Arm ankle Index|
Objective:To evaluate the effects of smoking on the antihypertensive efficacy and MCP-1,Hs-CRP,ADP and BaPWV,ABI of amlodipine.Methods:We selected120cases of mild to moderate male hypertensive patients,and they were divideded into smoking group (60cases) and non-smoking group (60cases). And all patients took amlodipine (5mg, Qd) for12weeks. Antihypertensive effect and the level of MCP-1,Hs-CRP,ADP,BaPWV,ABI were observed before and after treatment. And we selected60male who were non-smokers and whose physical examination were normal at the same time as a control group. MCP-1, Hs-CRP, ADP level were detected by ELISA,BaPWV and ABI were measured by arteriosclerosis detector.Results:1. Compared with the control group, the level of MCP-1, ADP, Hs-CRP and BaPWV in the non-smoking group were markedly different, but the level of ABI had no significant difference between the two groups,and all indicators in the Hypertension-smoking group had reached a significant difference(P<0.01).The level of MCP-1,BaPWV in the Hypertension-smoking group were higher than the non-smoking group, the level of ADP,ABI were lower,and the above indicators had a statistically significant difference (P<0.01), but the level of Hs-CRP had no significant difference between the two groups(P>0.05).2. After the treatment of amlodipine, the total effective rate of smoking group and non-smoking was53.3%,60%respectively,and there was no significant difference between the two groups.3.Compared with pre-treatment,there was only Hs-CRP reached statistical difference in smoking group, rather than the MCP-1, Hs-CRP, ADP level were all statistically significant in non-smoking group.4.Aafter the treament of amlodipine, the level of BaPWV and ABI in the non-smoking group were statistically significant,but the smoking group was no statistically significant.Conclusion:1.The level of inflammatory and arteriosclerosis factors in men with essential hypertension was significantly higher,and smoking can further aggravate the change.2. Smoking had no significant effect on antihypertensive efficacy of those mild to moderate male hypertensive patients who take amlodine.3.Amlodipine not only had an effect on antihypertensive,it is also in favour of reducing the level of inflammation status and atherosclerosis of those mild to moderate male hypertensive patients,but smoking can affect the role at the same time.