Status of Serum25-hydroxyvitamin D3in Essential Hypertensive Patients with Impaired Glucose Tolerance

Objective: To investigate the relationship between vitamin D and essentialhypertension(EH) with impaired glucose tolerance(IGT) by observing the status of serum25-hydroxyvitamin D3[25(OH)D3] and to explore the factors affecting D3[25(OH)D3].Methods:499cases of essential hypertensive inpatients (Oct.2010to Sep.2012) wereinvolved. All the subjects are of Han nationality including259males and240females,with the average age of (53.91±11.85). If the fasting plasma glucose (FPG) was normal,then did the oral glucose tolerance test(OGTT). According to the FPG and2hourspost-load glucose(2hPG), subjects were divided into two groups:(EH, n=309),(EH+IGT,n=190). Clinical data were compared between the two groups, and to analyze the serum25(OH)D3status differences. Results: EH+IGT patients showed decreased25(OH)D3level and increased vitamin D deficiency and insufficient rate as compared with EH cases[(12.01±4.83) ng/ml vs (13.23±5.70) ng/ml,99.5%vs98.4%, all P≤0.05]. Serum25(OH)D3level was higher among males in both group[EH,(14.24±5.81) ng/ml vs(12.19±5.39) ng/ml, EH+IGT,(12.99±4.99) ng/ml vs (10.88±4.40)ng/ml, P≤0.05].Serum25(OH)D3level and clinic systolic blood pressure (r=-0.321, P＜0.001), clinicdiastolic blood pressure (r=-0.343, P＜0.001) was negatively correlated, after the gender,age, duration of hypertension, body mass index, blood lipids and other factors werecorrected. Conclusion: Vitamin D deficiency and insufficient exists generally among theHan EH patients with IGT in Xinjiang. Serum25(OH)D3level decreases much obviously,especial among the female patients.