Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension

Investigate the Association between Rennin Angiotensin Ⅱ Type1Receptor(AT1R) Gene A1166C Polymorphism and Essential Hypertension in Chinese Han Population by the Means of Meta Analysis

Author WeiHaiYan
Tutor ZhangYuanMing
School Xinjiang Medical University
Course Internal Medicine
Keywords essential hypertension Rennin angiotensin Ⅱ type1receptor(AT1R) A1166C gene polymorphism gender
CLC R544.1
Type Master's thesis
Year 2013
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Objective:To Investigate the association between rennin angiotensin II type1receptor(AT1R)gene A1166C polymorphism and essential hypertension in Chinese Hanpopulation by the means of Meta analysis. Methods: retrieval comprehensively allliteratures about the association of A1166C gene polymorphism and essentialhypertension in Chinese Han population published in China national knowledgeinternet(CNKI),Wan fang full text database, Chinese biological medicine disk, Chinesescience and technology periodical full-text database,PubMed and Medline. And themconduct heterogeneity test, combine the effects across studies, sub-category analysis,publication bias and sensitivity analysis. Results:20articles of case-control studyconsistency were selected and8534people were included(4367people in hypertensiongroup,4167in control group).Hypertension group compared with the control, peoplecarrying C allele affected hypertension is pure AA genotype1.63times,the OR (95%CI)was [1.25-2.13],=4.70(P<0.00001);In the sub-category analysis of gender, comparedwith control group, male hypertension group owned AC+CC genotype vs. AAgenotype’s pooled OR (95%CI) was2.59,[1.74-3.85],=4.70(P<0.00001),The femalepopulation index was2.01,[1.34-3.03],=3.36,(P=0.0008).while Simply in hypertensionpatients, the female and the male comparative development for high blood pressure riskOR value is0.96with OR95%IC for[0.681.36],the total effect analysis=0.23(P=0.81).Conclusion: C allele increased the risk of developing hypertension, but no relegated withsex.

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