Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension

Effects of Atorvastatin Treatment on Blood Pressure in Senile Hypertension Patients with Normal Blood Lipids

Author YuanLiLi
Tutor ZhaoShuiPing
School Central South University
Course Internal Medicine
Keywords Atorvastatin Hypertension Senile Normal blood lipids
CLC R544.1
Type Master's thesis
Year 2012
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OBIJECTIVE:To observe the effects and safety of atorvastatin treatment on blood pressure in senile hypertension patients with normal blood lipids.METHODS:In cardiovascular department of the second people’s hospital of hunan province,120senile hypertensive patients with normal blood lipids were randomly divided into two groups (routine anti-hypertensive treatment group and combined statin intervention group). All the patients were treated with traditional anti-hypertensive treatment, and the combined statin intervention group was treatment with additional atorvastatin. The change of blood pressure and biochemical index were observed, and the adverse reactions were recorded.RESULTS:The level of systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were decreased notably after4or8weeks of treatment, the differences were statistical significance (p<0.05). But between routine treatment group and statin intervention group, the blood pressure indexes had no difference (p>0.05). According to blood pressure levels, patients were divided into two sub-groups. In grades1and2hypertension sub-group, there was no difference between routine treatment group and statin intervention group (p>0.05). And in grade3hypertension sub-group, the SBP and PP of statin intervention group were significant decreased than routine treatment group (p>0.05). There is no correlation between antihypertensive and lipid-decreasing effect of atorvastatin (p>0.05).CONCLUSION:After antihypertensive treatment, blood pressure levels in patients were decreased. In grade3hypertension group, atorvastatin has a synergistic effect in anti-hypertensive treatment. The anti-hypertensive effect of atorvastatin has no correlation with its lipid-lowering effect.

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