Analysis of risk factors of different glycyrrhizic acid preparations caused low blood potassium
|School||Beijing University of Traditional Chinese Medicine|
|Keywords||Glycyrrhizin Hypopotassemia Risk factor|
OBJECTIVE:Understand the usage of Glycyrrhizin in a class3first level general hospital; Analyze various factors of patients that use Glycyrrhizin and discover the risking factors that lead to hypopotassemia for usage of Glycyrrhizin; Provide suggestions for clinicians to enhance care and adjust pharmacy, in order to reduce the incidence and severity of hypopotassemia and reduce the risk of usage of glycyrrhizin.METHODS:Research objects were patients that used Glycyrrhizin during the course of treatment in a class3first level general hospital of Beijing. Select treatment information of patients as research data of this paper that had ever used Magnesium Isoglycyrrhizinate Injection and Compound Glycyrrhizin Injection between September2012and May2013. The tool of investigation is Hospital Information System (HIS) and information was recorded in the self-made questionnaire of Glycyrrhizin. The questionnaire divided into4sections that were General information of patients and usage of Glycyrrhizin、unpleasant reaction caused by drug usage、combination of various drugs、results of auxiliary examination.The data collected with the same questionnaire for patients using Glycyrrhizin were input to computer using Excel2007. For the follow-up further analysis, we analyze characteristics of clinical usage of Magnesium Isoglucurrhizinate Injection and Compound Glycyrrhizin Injection. After one-way logistic regression analysis for the qualified variables multiple logistic regression was used for selecting the influencing factors to establish the best regression model. All the analyses were analyzed with Exce12007and SPSS20.0.RESULTS:(1) Demographic characteristics of patients that have used the Magnesium Isoglycyrrhizinate Injection.256patients using Magnesium Isoglucurrhizinate Injection mainly concentrated in liver and gallbladder surgery department and onset, and the majority were male and their ages concentrated in45～59,60～74years old.39.84%of the patients are suffering from a chronic disease. Most of patients have no bad habit, except some male patients who build habits of drinking and smoking. Patients that use drug to improveabnormal liver function accounts for72.27%. The clinical course of injection is one to two weeks. Based on analysis, daily dose of Magnesium Isoglycyrrhizinate Injection is20～40ml, which is also recommended by instructions.(2) Demographic characteristics of patients that have used the Compound Glycyrrhizin Injection.There are465cases of patient information of using Compound Glycyrrhizin Injection in investigation and study time and mainly concentrated in the Department of hepatobiliary surgery, Department of Hematology and thyroid and breast surgery, which account for44.94%. The proportion of male and female patient does not have the obvious difference. Ages of patients concentrated in45～59,60～74years old, which account for61.51% and there are11cases of newborn infants under one year old using Compound Glycyrrhizin Injection.Compound Glycyrrhizin Injection is mainly for prevention and abnormal liver function improvementin clinical, which accounted for90.11%. There was also one case in the treatment of dermatitis. Most of patients have3chronic diseases. The course of treatment is1～2weeks and the daily dose of Magnesium Isoglycyrrhizinate Injection is60～80ml.(3) Influencing factors of hypopotassemia caused by Glycyrrhizinpreparation. Based on the analysis with Logistic regression model, the main influencing factors that lead to hypopotassemia after usage of Glycyrrhizin include gender、 process of treatment、potassium level before drug usage and usage of efflux of potassium diuretics. Based on the correlated analysis between gender and bad habits (such as drinking), it found correlation among variables in different levels.CONCLUSION:(1) Most of departments tend to choose Compound Glycyrrhizin Injection, and only a few departments would use the Magnesium Isoglycyrrhizinate Injection. Within the same time period, the usage of Compound Glycyrrhizin Injection much larger than that of Magnesium Isoglycyrrhizinate Injections.(2) Most of young and middle-aged patients tend to use the Compound Glycyrrhizin Injection, and most of elderly patients tend to use the Magnesium Isoglycyrrhizinate Injection. Compound Glycyrrhizin Injection would be used for infants and young children of abnormal liver function.(3) The study found that the Compound Glycyrrhizin Injection can not only be used for improvement of abnormal liver function but also has a good effect for preparation. However, the Magnesium Isoglycyrrhizinate Injection is mainly used for improvement of abnormal liver function.(4) In the view of daily dose, dosage of the Compound Glycyrrhizin Injection is more than that of the Magnesium Isoglycyrrhizinate Injection. However, after calculation, the real effective components of the Compound Glycyrrhizin Injection are relatively less.(5) The main risk factors of hypopotassemia after using Magnesium Isoglycyrrhizinate Injections were gender, days of treatment, blood potassium before treatment, refrigerant diuretic.(6) The main risk of hypopotassemia after using Compound Glycyrrhizin Injection may be gender, days of treatment, blood potassium before treatment, potassium drug is used, reasons for drug usage and the use of potassium diuretics.(7) Logistic regression was used to study risk factors for disease.