Dissertation > Medicine, health > Pediatrics > Children within the science > Pediatric Infectious Diseases

Study on Epidemiology and Risk Factors Associated with Repeated Infection Case of Hand-food-mouth Disease in Maanshan City

Author ChaBing
Tutor WangJianJun
School Anhui Medical University,
Course Public Health and Preventive Medicine
Keywords Hand-foot-mouth disease Epidemiology Enterovirus71 Coxsackievirus A16 prevention and control Reinfection Risk factor
CLC R725.1
Type Master's thesis
Year 2013
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ObjectiveThe main purpose of this study is to analyze HFMD (hand-foot-mouth disease)epidemic data in Ma’anshan from2008to2011, describing the epidemiologicalcharacteristics, etiology composition and diversion of HFMD incidence. To explore themultiple infections incidence of HFMD, epidemiological characteristics of cases andrepeated infection time interval and case-control study was carry out to explore themajor risk factor of repeated infections at the same time so as to provide evidence fordisease control and prevention of HFMD.MethodsInformation of Ma’anshan HFMD case from2008to2011was exported from "TheChina Disease Surveillance Information Report Management System". The incidencerate, age composition ratio, sex ratio, etiology composition ratio were analyzed toexplore three intervals distribution of Ma’anshan HFMD. Repeated infected cases werescreening according to preset criteria of multiple infection so as to explore the incidenceof multiple infections and their characteristics. A case-control study of risk factors formultiple infections was carried out to analyze the risk factors HFMD single onset andmultiple infections between all cases (multiple infections case group) and the sameamount of single onset and healthy children using convenience sampling method,matched age and gender. In factors survey foot and mouth disease infected childrenwere using SPSS11.5software was used to apply the non-conditional Logisticregression analysis. ResultsFrom2008to2011, a total of7583cases of HFMD were reported. The averageannual incidence rate of HFMD was129.46/100000, while incidence of2010being thehighest (262.23/100000), incidence of2008being the lowest (56.97/100000). Theonset of HFMD was mainly from April to July, the percent of cases from April to Julybeing64.25%. The cases were mainly in the1-4age groups, accounting for82.76%.Male to female ratio was1.54:1. Pathogen monitoring results shows that the positivesamples in2009were all Enterovirus71(EV71). But in2010, the positive samples weremainly Coxsackie virus group A, type16(CoxA16), accounting for60.71%in positivesamples, while the main positive samples being EV71in2011(accounting for69.71%).Among7583HFMD cases from2008to2011,294cases were infected for twotimes or more, while the rate being3.88%. The sex ratio was1.75: l. The cases weremainly in the1-4age groups, accounting for92.52%. The cases were mainly in the1-4age groups, accounting for92.52%. The peak incidence of infection of repeatedinfection was similar with total peak incidence of the city.62.24%of multiple infectionsoccurs in one year after the initial infection. In the same year and the second year, theoccurrence of repeated infections accounted for30.27%and53.74%. Many cases ofinfection were diagnosed in laboratory (accounted for10.88%) mainly in the EV71type (accounting for59.38%).Univariate analysis shows that, the risk factors of single incidence of HFMD arechildren categories, physical status, family type using the toilet, family housing types,while those of repeated infections being partial eclipse, parents with habits ofbuying snack in roadside shops for their children, and parents with habits of sharingdrinks and food with children.In multivariate analysis, living in cottage was the risk factor for single HFMD,with1.656times to the risk of living building housing. Scattered students as the control,the risk of children and kindergarten children suffering from HFMD were increasedthan scattered children (6.729times and1.851times). Children with no partial eclipse and not sharing drinks or food with children was the protective factors for repeatedinfections, with a risk of0.604times0.545times to those children with partial eclipsebehavior and sharing with drink or food parentsConclusionsThe incidence of HFMD in Maanshan was high, with obvious seasonalcharacteristics in morbidity and population distribution. The major type of HFMD wasdifferent, with in2009and2011mainly for EV71and2010year principal of CoxA16.The incidence of HFMD in1-4year group was high, with type of intestinal virus beingmainly EV71.To strengthen the prevention and control of HFMD among children andthat living in cottage. Health education, advocacy for children a balanced diet, notsharing food and drink with adults can reduce the incidence of repeated infections ofHFMD, maintaining a healthy lifestyle and good habits.

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