Dissertation > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke) > Cerebral embolism

The Incidence and Related Risk Factors Analysis of Vascular Cognitive Impairment in Inpatients with Cerebral Infarction

Author FangZuo
Tutor GaoZheng
School Dalian Medical University
Course Neurology
Keywords acute cerebral infarction vascular cognitive impairment(VCI) montreal cognitive assessment scale MoCA risk factors
CLC R743.33
Type Master's thesis
Year 2013
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Objective: Investigate the incidence and its risk factors of vascular cognitiveimpairment (VCI) in the inpatients with cerebral infarction.Methods: Selecting110hospitalized patients which diagnosed as cerebralinfarction and post-stroke depression (PSD) is excluded according to ICD-10F32at themean time, from March2012to November2012of Neurology Department in theSecond Affiliated Hospital of Dalian Medical University. Utilize the MontrealCognitive Assessment (MoCA) Beijing Version to screen and assess all the patients, ofwhich72cases were assigned to VCI group while38cases to group without VCIaccording to the result of MoCA.1. To statistics the incidence of VCI in the inpatients with cerebral infarction andthe incidence variation of VCI with the increasing number of cerebral infarction.2.To conduct single factor analysis separately between groups with and withoutVCI, selecting gender, age, body mass index, education years, smoking, drinking,diabetes, atrial fibrillation, hypertension, carotid artery atherosclerosis, Alba loosefactors, etc. To learn about the factors mentioned above whether or not there werestatistical differences between the two groups.3. To introduce factors with statistical differences that after single factor analysisinto multi-factors unconditional Logistic regression analysis model, utilize VCI asdependent variable to conduct multi-factors statistics analysis, learn about independentrisk factors that related to VCI.Results:1. The incidence of VCI:The VCI incidence of inpatients that with cerebral infarction is65.46%. With theincreasing number of cerebral infarction, the incidence of VCI becomes much higher. The VCI incidence of the first time cerebral infraction is64.20%, twice or more cerebralinfarction’s VCI incidence is68.97%.2. Single factor analysis:In general conditions, education level has significant statistical meaning incomparation between VCI group and group without VCI(P<0.01). In Vascular riskfactors, alba loose has statistical meaning in comparation between VCI group and groupwithout VCI (P<0.05). Hypertension, diabetes and carotid artery atherosclerosis havesignificant statistical meaning in comparation between VCI group and group withoutVCI (P<0.01)3. Logistic regression analysis:Education years (OR=0.862,95%CI:0.748-0.993, P=0.039), carotid arteryatherosclerosis(OR=3.322,95%CI:1.285-8.586,P=0.013),Hypertension(OR=2.653,95%CI:1.023-6.879, P=0.045), diabetes (OR=7.074,95%CI:2.097-23.867, P=0.002), theabove four variables have statistical meaning (P<0.05).Conclusion:1. The incidence of VCI in the inpatients with cerebral infarction is65.46%. Themore cerebral infarction numbers increase, the higher incidence of VCI occurs.2. The lower education years, the easier of VCI to be occurred; Hypertension,diabetes, carotid artery atherosclerosis and alba loose may be the risk factors which leadto VCI occurring.3. The low education years, carotid artery atherosclerosis, hypertension anddiabetes are independent risk factors of inpatients with cerebral infarction VCIoccurring.

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