Expression of VEGF in Glioma and Its Association with the Prognosis
|School||Central South University|
|Keywords||VEGF Glioma Pathological grade Prognosis|
OBJECTIVETo examine the expression of Vascular Endothelial Growth Factor (VEGF) in different pathological grade glioma, and investigate its relation to tumor malignant degree and prognosis, with several clinical factors.METHODSSP immunohistochemical technique was used to detect the expression of VEGF in120cases of different pathological grade brain glioma and10cases of normal brain tissue. And all data was analyzed with SPSS16.0package. Chi-square test was used to judge the otherness of VEGF expression in different pathological grade brain glioma. Survival time was defined as dependent variables, and then Kaplan-Meier method was used to analysis the impacts of expression of VEGF and several clinical factors to the survival time. Differences in survival between each group were tested for statistical significance by the log-rank test. After that, multivariate COX regression analysis was performed to identify independent prognostic factors with P<0.05in the results of univariate analysis. RESULTS1. There is no expression of VEGF in normal brain tissues, and there are17cases of VEGF expression in low grade which account for28.81%, and37cases in high grade which account for60.66%. By the chi-square test, the expression of VEGF was significantly different between low grade and high grade gliomas (P<0.05).2. By univariate analysis, pathological grade of tumor, postoperative radiotherapy, preoperative KPS score and the expression of VEGF are significantly associated with prognosis.3. By multivariate COX regression analysis, only pathological grade of tumor, preoperative KPS score and the expression of VEGF are independent risk factor to prognosis.CONCLUSIONS1. The expression of VEGF in brain glioma correlates with the pathologic grade of tumor.2. The expression of VEGF, pathological grade of tumor and preoperative KPS score are independent risk factors for prognosis of brain glioma patient. The glioma patients with obviously expression of VEGF, low preoperative KPS score and high pathologic grade have the shorter life spans.