Dissertation
Dissertation > Medicine, health > Neurology and psychiatry > Psychiatry > Cerebral organic mental disorder > Elderly as early as possible the old disorder

Study on the correlation between aMCI and MTA-scale in patients with AD score difference and TCM Syndrome Elements

Author MaJingZuo
Tutor TianJinZhou
School Beijing University of Traditional Chinese Medicine
Course Traditional Chinese Medicine
Keywords mild cognitive impairment neuropsychology MTA-scale forMedial Temporal lobe Atrophy
CLC R749.16
Type Master's thesis
Year 2014
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Objective:To study the difference of MTA-scale for Medial Temporal lobe Atrophy score (hereinafter referred to as the MTA-scale score) among aMCI (amnestic mild cognitive impairment) group, AD (Alzheimer’s disease) group, NC (cognitively normal) group, and to explore the correlation between MTA-scale visual score and syndromes factor.Method:According to Petersen et MCI diagnostic criteria established in1999, the U.S. National neurology, language barriers and Stroke Research Institute-Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) criteria for Alzheimer’s disease diagnostic studies (dementia diagnostic reference to DSM-IV), aged45-85years old on185complaints of memory loss in the subjects tested. I screened53patients with aMCI group,11patients with AD group,9cases of cognitively normal group, and the remaining112cases, including cancer, depression and anxiety, with implanted metal and unwilling to accept brain MRI and other patients. All enrolled subjects for demographic data collection, neuropsychological evaluation, Syndrome Factor score, and cranial magnetic resonance imaging (MRI), and MTA-scale score. Mean comparison between groups using non-parametric test, measurement data using the Spearman correlation coefficient.Results:1. Demographic data:the average age of AD group (69.73±9.25) is higher than the aMCI group (61.68±8.89, p=0.030), while those in NC group (61.67±4.90,p=0.012).2.Neuropsychological Scale:MMSE scores NC group group(28.44±1.509) was significantly higher than aMCI group (26.11±2.391, p=0.005), aMCI group was significantly higher than the AD group (17.91±4.742, p=0.000), NC group significantly higher than the AD group (p=0.000). Clock drawing test scores AD group (2.55±1.128) was significantly lower than aMCI group (3.49±0.912, p=0.002) and NC group (3.78±0.667, p=0.005).3. MTA-scale score:AD group on the left scores (2.14±1.142), the right of scores (2.23±1.104) and total score (4.36±2.075) were significantly higher than aMCI group (0.59±0.944,0.67±0.871,1.26±1.753, p=0.000,0.000,0.000), AD group scores the left and right scores and total scores were significantly higher than NC group (0.33±0.500,0.39±0.486,0.72±0.972,p=0.000,0.000,0.000).MMSE<26on the left grouping MTA-scale score (1.16±1.214), on the right score (1.27±1.170) and total score (2.43±2.328) were significantly higher MMSE>26group (0.40-0.791,0.46±0.690,0.86±1.387, p=0.000,0.000,0.000). left and right side of the sccre and the score of the Spearman correlation coefficient (Correlation Coefficient) were-0.504,-0.535,-0.539, p=0.000,0.000,0.000.4. MTA-scale scores and factor correla-tion syndromes:TCM syndrome elements of the AD group qi, blood stasis reducing marrow, Yang Kang is the main syndrome elements, aMCI group yang hyperactivity, kidney, qi, phlegm as the main card Su, NC group Yang Kang, Qi, marrow subtraction, Su Yang as the main card. AD and aMCI group and more patients than a single card syndrome element muoti-prime and prime undocumented patients, no difference in NC patients certificate hormone levels. Complained of memory loss in the crowd, MTA-scale scores with the left qi correlated (Spearman correlation coefficient was0.433, p=0.039). MTA-scale right side of the score and phlegm correlated (Spearman correlation coefficient was0.516, p=0.041). aMCI patients MTA-scale scores and phlegm left and right with a strong correlation (Spearman correlation coefficients were0.677,0.671, p=0.011,0.012).Conclusions:1) As the disease gradually aMCI progress to AD, the medial temporal lobe (hippocampus) atrophy increased. Medial temporal lobe atrophy using visual rating scale (MTA-scale) can effectively differentiate AD from normal aging.2) The lower MMSE scores, MTA-scale the higher the score, the more severe the medial temporal lobe (hippocampus) atrophy.3) AD group qi xu, blood stasis, phlegm, deficiency of the kidney,yang kang is the main syndrome elements, aMCI group deficiency of the kidney.yang kang, qi xu, blood stasis,phlegm as the main evidence hormone, NC group qi xu,yang kang, deficiency of the kidney is the main elements of the permit. AD and aMCI group and more patients than a single card syndrome element multi-prime and prime undocumented patients, no difference in NC patients certificate hormone levels, indicating that as the decline in cognitive function, leading to the gradual complication of the disease, thus demonstrating the complex syndrome elements.4) complained of memory loss in the crowd, along with the severity of the patient, the left medial temporal lobe (hippocampus) atrophy more serious. With the severity of phlegm, right medial temporal lobe (hippocampus) atrophy more serious.5) In the aMCI group of patients, with increased phlegm degree of MCI patients bilateral medial temporal lobe (hippocampus) atrophy is more serious.

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