A retrospective clinical study of xiaoaiping injection on peripheral blood of the patients with malignant tumor chemotherapy effect
|Beijing University of Traditional Chinese Medicine
|Traditional Chinese Medicine
|malignant cancer chemotherapy retrospective clinical study peripheralhemogram non-small cell lung cancer Xiaoaiping Injection
Malignant cancer has become the disease that threatens the human health and life the most in the world. And its morbidity has been increased by3to5percent throughout the world with a sharp raise of morbidity and mortality in many countries. For curing it, chemotherapy is one of the most common methods for both patients whose tumors have or have not been surgically removed. Clinical practice has proven that chemotherapy contributes a lot in removing tumors left after operations, lightening tumor load, alleviating the problem, preventing complications and improving patient’s quality of life. However, it can lead to numerous toxic and side effects, such asmyelosuppression, hepatorenal function damage, adverse reactions of gastrointestinal tract, and peripheral neuropathy. Among these side effects, myelosuppression, characterized by peripheral hemogram decrease, is the most common complication that greatly affects the completion of chemotherapy in clinical practice in that almost all chemotherapy drugs have strong clinical hematologic toxicity. Even seriously, this complication cannot be prevented with certain medication until it occurs. It is because that the effects of different chemotherapy drugs on peripheral hemogram vary greatly and that their occurrence time cannot be accurately predicted. What is more, western medicine treatment of myelosuppression has shown many disadvantages. For one thing, it adds burdens upon both medical expenses and patients’ bodies. For another, it influences the therapeutic effects of chemotherapy drugs through limiting drugs to lower dose and proponing chemotherapy. Alternatively, chemotherapy combined with Traditional Chinese medicine injection is currently the most common therapy for treating malignant cancer in China. And in clinical practice, we found that Xiaoaiping Injection alleviated chemotherapy-induced blood platelet decrease.Objectives:Part I:The aim of this study is to observe and evaluate the protective effect of Xiaoaiping Injection on peripheral hemogram of patients who received chemotherapy for malignant cancer through a retrospective clinical study.Part Ⅱ:The aim of this part is to observe and assess the effect of Xiaoaiping Injection on protecting peripheral hemogram, treating qi and blood deficiency pattern and improving quality of life of patients who underwent chemotherapy for non-small cell lung cancer (NSCLC) through retrospective clinical study.Methods:Part I:Subjects were included from malignant cancer in-patients who were treated with chemotherapy in Department of Oncology and Hematology, Dongzhimen Hospital. According to the therapy they received,these patients were divided into two groups:treatment group (chemotherapy combined with Xiaoaiping Injection) and control group (chemotherapy only). Then, peripheral hemogram was detected and the effect of Xiaoaiping Injection on peripheral hemogram of patients who underwent chemotherapy was observed. Part Ⅱ:Subjects were included from NSCLC in-patients who underwent chemotherapy in Department of Oncology and Hematology, Dongzhimen Hospital. These patients were divided into two groups according to the therapy they received:treatment group (chemotherapy combined with Xiaoaiping Injection) and control group (chemotherapy only). Then, their peripheral hemogram, score of qi and blood deficiency pattern and quality of life were detected. The effects of Xiaoaiping Injection on protecting peripheral hemogram, treating qi and blood deficiency pattern and improving quality of life of patients who received chemotherapy treatment for NSCLC were also assessed.Resualts:Part Ⅰ:Eighty-eight patients were included in this study with44patients in each group. On Day8of chemotherapy, average blood platelet (PLT) in treatment group was (175.52±61.12)×109/L while that in control group was (167.15±42.83)×109/L, which showed a statically significant difference (p<0.05) between this two groups. The difference in mean platelet volume (MPV)of this two groups was also statically significant (p<0.05) with (8.30±1.46)fl and (10.18±1.46)fl in treatment group and control group respectively. However, there is no significant difference (P>0.05)between the two groups on regards of white blood cell, neutrophile granulocyte or hemoglobin.Part Ⅱ:Sixty-four patients were included in this study with31in treatment group and33in control group. On Day8of chemotherapy, average PLT in treatment group and control group were (223.71±95.31)×109/L and (173.48±52.51)×109/L respectively. And the MPV in treatment group and control group were (8.22±1.18) fl and (10.45±.55) fl respectively. Both PLT and MPV of this two groups were statistically significantly different (p<0.05). On the contrary, there is no significant difference between the two groups in white blood cell, neutrophile granulocyte or hemoglobin (P>0.05).The therapeutic effects for treating qi and blood deficiency pattern on Day8of chemotherapy:in treatment group,0case was markedly effective,0case was effective,11cases were slightly effective and20patients were ineffective; and in control group,0case was markedly effective,0case was effective,6cases were slightly effective and27patients were ineffective. By comparison,there was no significant difference(P>0.05) in the two groups on treating qi and blood deficiency pattern.The curative effects of two groups on KPS on Day8of chemotherapy showed a significant difference(P<0.05) with3cases improved,12cases stabilized and16cases declined in treatment group and4cases improved,6cases stabilized and23cases declined in control group.Conclusion:1. Xiaoaiping Injection can alleviate the chemotherapy-induced blood platelet decrease in malignant cancer patients.2. Xiaoaiping Injection can alleviate the chemotherapy-induced blood platelet decrease in NSCLC patients.3. Xiaoaiping Injection can improve the quality of life of NSCLC patients during and after chemotherapy.