Dissertation > Medicine, health > Oncology > Respiratory system tumors > Lung tumors

Analysis of 52 cases with advanced non small cell lung cancer serum tumor markers

Author ZhangAoZhe
Tutor ZhuShiJie
School Beijing University of Traditional Chinese Medicine
Course Traditional Chinese Medicine
Keywords non-small cell lung cancer CEA CA125 CA153
CLC R734.2
Type Master's thesis
Year 2014
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ObjectiveTo assess the clinical value of serum carcinoem bryonic antigen (CEA), carbohydrate antigen125(CA125), carbohydrate antigen15-3(CA153) at base line in patients with advanced non-small cell lung cancer (NSCLC).MethodThis assay was a retrospective study of patients admitted to integrated traditional Chinese medicine (TCM) and western medicine (WM) medical department of China Japan friendship hospital from1st of January of2010to1st of May of2014. Levels of CEA, CA125, CA153in serum were studied in52patients with advanced NSCLC. Data were correlated with prognostic value, histological subtypes and Epidermal Growth Factor Receptor (EGFR). Kaplan-Meier survival and Cox regression were used to analyze the relationship of serum tumor markers and the prognosis. Log-rank test and Logistic regression were used to analyze the correlations between serum tumor markers with histological subtypes and EGFR.ResultsBasic information:52cases were all treated by integrated TCM and WM. Among which33were males and19were females (63.5%vs36.5%). Ages were form45years old to83.Adenocarcinoma were42,Squamous cell carcinoma were9,large cell caicinoma were2(80.8%vs17.3%vs1.9%).TNM stage:Ⅲb we:e9and IV were43(17.3%vs82.7%). EGFR positive were13and EGFR negative were19. Overall Survival was16.1months ranging from1month to67months. One-year survival rate was53.8%, two-year survival rate was30.8%, three-year survival rate was23.1%, five-year survival rate was1.9%.The high level of serum CEA was good prognostic factor while the high level of CA125was poor for OS, showing a significant statistical difference (P<0.05). But the level of serum CA153didn’t show a significant statistical difference (P>0.05).For the histology subtypes and EGFR. The level of serum TM did not showing a significant statistical difference (P>0.05).Conclus ionSerum CEA, CA125levels appeared to be reliable surrogate markers of prognos is and CA153was less reliable in patients with advanced NSCLC. Serum CEA, CA125, CA153levels shows no correlations with histological subtypes and EGFR status.

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