Dissertation > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms

The Clinical Characteristics, Diagnosis and Treatment of Gastric Stromal Tumor:a Report of54Cases

Author XuZhiQiang
Tutor XingGuangMing
School Dalian Medical University
Course Surgery
Keywords Gastric stromal tumor(GST) CD117 CD34 clinical features diagnosis treatment
CLC R735.2
Type Master's thesis
Year 2013
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Objective: Through discussing the clinical manifestations, auxiliary examination,diagnosis and treatment methods to improve our knowledge of the diagnosis andtreatment of the Gastric stromal tumor(GST).Methods: Through systematical retrospective analysis of54cases of The SecondAffiliated Hospital of Dalian Medical University from2002to2010,which all treatedthrough operation and diagnostical as GST with the help of Pathological examination,retrospectively analyze the patients clinical data include: age, gender, clinicalmanifestations, relevant auxiliary examination, surgical approach, postoperativepathology, Pathological risk classification, Immunohistochemical data to find out partsof the patients prognosis and know some postoperative patients taking imatinib andprognosis.Results:54cases was included in our research,24cases manifested as abdominalpain or discomfort as the first symptom;15cases manifested as gastrointestinal bleed bywith black stool as the main symptom;3cases had abdominal mass,7cases hadbloating and12cases found GST through physical examination.37patients receivedGastroscopy examination,3had X-ray Barium meal,26had abdomen CT scan including16patients whom had Enhanced CT Scan pre-operation.9had abdominal Ultrasound,8had Gastroscopy Ultrasonic examination in other hospitals. All the patients were treatedby operation and all of them were diagnosis as GST with the IHC of CD117, CD34andso on. Taking Imatinib regularly post-operation has advantages for the GST patients,especially for those high risk patients.Conclusion:1.There is no difference between men and women in GST incidence, the greaterand lesser curvature of the gastric body are the main primary sites.2.The diagnosis of GST is mainly rely on the Gastroscopy examination,Gastroscopy Ultrasonic examination is significantly better than the abdomen ultrasound, on CT or some other examinations.3.The confirming of the diagnosis is mainly depend on the Pathologicalexamination.4.The main treatment of GST is operation. Mitotic count and tumor size are foundto be important indication of the prognosis. After operation the regular use of imatinibon prognosis of patients is effective, especially in high risk patients.

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