Analysis of the Relationships between Clinicopathologic Factors and Prognosis of Gallbladder Cancer
|School||Second Military Medical University|
|Keywords||Gallbladder carcinoma multivariate analysis Clinical pathology prognosis|
ObjectiveThis study elucidated the relationships between various clinicopathologic factorsand the outcome of patients with gallbladder cancer (GBC) treated by surgicalresection with curative intent.MethodsBetween December2003and December2009,170patients with GBC underwentsurgical resection with curative intent at our department. We then conducted aretrospective analysis of clinicopathologic data. eighteen clinicopathological variableswere selected for univariate and multivariate analysis to evaluate their influence onthe outcome.Results1. The median survival time was12.5months, and the actuarial0.5-,1-,2-,3-,and5-year survival rates in the170resected cases were68.8%、50%、35.9%、31.5%and23.6％（Fig.1）respectively.2. The univariate analysis showed that preoperative jaundice, serum level ofCAl9-9, serum level of CEA, curative resection,lymph node metastasis, intraoperativeblood loss,tumor location, histologic differentiation, TNM stage, and Unexpected gallbladder carcinoma significantly correlated with the prognosis of the patients (p<0.05).3. The results of the multivariate analysis (Cox regression) showed TNMstage,tumor location on gallbladder neck, lymph node metastasis and curativeresection were independent prognostic factor for the patients with gallbladder cancer.ConclusionTNM stage, tumor location on gallbladder neck, lymph node metastasis and thesurgical approach are independent prognostic factors for gallbladder cancer, a rapidlyfatal disease. Therefore, early diagnosis, standardizationtreatmentand radical surgeryare greatly needed to improve the prognosis of gallbladder carcinoa.