Study on the Contralateral Neck Lymph Node Metastases of Oral Squamous Cell Carcinoma
|School||Central South University|
|Keywords||oral squamous cell carcinoma contralateral lymph nodemetastases ipsilateral lymph node metastases tumor extension across themidline extracapsular spread tumor location histologic grade prognosis|
Objective:1. To explore the relationship between contralateral lymph node metastases of oral and orpharyngeal squamous cell carcinoma (SCC) and the pathophysiological factors。Methods:We review659patients with OSCC treated by combined radical operation in the Department of Stomatology, the Second Xiangya Hospital of Central South University from Jan2008to Dec2012and69patients for CNLM. By reviewing the clinical history and histologic data. The prognostic influence of different clinicopathologic factors in contralateral lymph node met The log-rank test was used for survival analysis of contralateral metastases. Correlation between different clinicopathologic factors and the presence ofcontralateral metastases was studied with the x2test for univariate analysis and logistic regression for association of these factors and contralateral metastases in the multivariate analysis (P<0.05).Results:There are69patients(10.47%) have positive contralateral metastases, of the659patients.28patients (4.10%) had primary positive contralateral metastases in neck dissection specimens and41patients (6.37%) had contralateral recurrences at follow-up. Ipsilateral lymph node metastases and extension across the midline were the most important predictors of contralateral metastases (P<0.05) on multivariate logistic regression analysis. More likely to contralateral neck lymph node metastasis of oral squamous cell carcinoma growth in the floor of the mouth and the base of tongue(P<0.05).Conclusion:1. Tumor invasion of the midline and ipsilateral cervical lymph node metastasis are the important factor for the occurrence of contralateral neck lymph node metastasis.2. Oral squamous cell carcinoma growth in the floor of the mouth and tongue more easily lead to the contralateral neck lymph node metastasis.3.Patients with ipsilateral cervical lymph node pN0have risk for contralateral neck lymph node metastasis.