Dissertation > Medicine, health > Pediatrics > Children within the science > Pediatric endocrine diseases and metabolic diseases

Congenital Hypothyroid Function Thyroid Screening Analysis

Author CuiYongMei
Tutor XiaYuJun
School Qingdao University
Course Human Anatomy,Histology and Embryology
Keywords Congenital hypothyroid function Morbidity Thyroid Etiology and Classification Screening
CLC R725.8
Type Master's thesis
Year 2011
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Objective:Congenital hypothyroidism (congenital hypothyroidism, CH) is due to congenital factors make thyroid secretion is reduced, leading to children with growth disorders, mental retardation, is one of the common endocrine diseases in pediatrics. Development of children with congenital hypothyroidism thyroid imaging studies, to further elucidate the etiology, pathogenesis, clinical treatment has important significance. Author of our city from 1998 April to 2010 June and screened in 553 cases of children with congenital hypothyroidism were thyroid imaging change research.Materials and methods:April 1,1998 to June 30,2010 object City area hospitals at all levels hospital delivery of live births and diagnosed with CH.Specimens collected from neonates born to 72h, from heel medial or lateral blood 2~3 drops in the SchleicherSchuel1903 filter paper, natural shade drying, put the plastic bag sealed 0~4, and delivered to the laboratory unified detection. Suspected neonatal collecting venous blood serum separation-20 DEG C, after cryopreservation.The detection method for CH screening experiments using enzyme labeling method for the determination of filter paper thyrotropin (TSH) content, limit point of 20 u U/ml. CH diagnosis using radioimmunoassay of serum TSH, total and/or free thyroxine (T4 three), triiodothyronine (T3) content.Diagnosis and treatment of when screening the experimental results above cut-offs, confirmed experimental elevation of serum TSH, T4 or/and T3 decreased, and in combination with the clinical manifestations can be diagnosed with CH; if only elevated TSH, T4 or/and T3 normal, then every 30 days continuous six months to confirm the diagnosis. In thyroid imaging diagnosis on CH confirmed cases before treatment for radionuclide thyroid static imaging (99mTcO4 American GE company ECT) or color ultrasonic (Toshiba 340 and Philips IU22 three-dimensional color ultrasonic examination, thyroid location), development and function determination.Results:in 908733 cases of neonatal screening out of children with congenital hypothyroidism in 553 patients, the incidence of 1:1643; 553 CH thyroid scan revealed normal thyroid 351 cases, dysplasia 69 cases,52 cases of ectopic,42 cases, 39 cases of poor uptake function. Thyroid abnormalities in CH is the permanent CH; 492 cases of etiologic classification of CH,267 cases of permanent CH,225 cases with temporary CH; after treatment with CH bone age and intelligence development.Conclusion:permanent and temporary CH thyroid morphology, location change, for congenital hypothyroidism etiology, diagnosis, treatment and prognostic judgment basis.

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