Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)

The Changes and the Clinical Significance of Serum Ischemia Modified Albumin, Soluble Intercellular Adhesion Molecule 1 and C-reactive Protein in Patients with Coronary Heart Disease

Author LinChangYong
Tutor ChenZuoYuan
School Qingdao University
Course Internal Medicine
Keywords Coronary artery disease Ischemia-modified protein Cell adhesion molecule C-reactive protein
CLC R541.4
Type Master's thesis
Year 2011
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Objective To investigate the coronary heart disease (CHD) patients ischemia-modified protein ( IMA ) , soluble intercellular adhesion molecule -1 (sICAM-1) and high-sensitivity C-reactive protein (hs-CRP) changes and corresponding significance . Methods acute myocardial infarction (AMI) patients , patients with unstable angina pectoris (UAP) , stable angina pectoris (SAP) patients , 20 cases by measuring its serum IMA , sICAM -1 and hs-CRP change with 20 Example healthy subjects as a control group for comparison. Result AMI sera IMA , sICAM- 1 and hs-CRP were higher than the UAP patients , SAP patients and the control group (F = 76.52,29.75,12.90, q = 6.08-59.02, P lt; 0.01); UAP serum IMA sICAM-1 and hs-CRP levels were significantly higher than in SAP patients and the control group ( q = 4.30-181.90 , P lt ; 0.01 ) , SAP serum IMA , sICAM - 1 and hs-CRP and the control group there are some differences between the ( q = 4.97,8.58,2.82, P lt; 0.01). Different types of CHD patients serum IMA, sICAM-1 and hs-CRP levels was a significant positive correlation between (IMA sICAM-1 r = 0.537, between IMA and hs-CRP r = 0.699 , sICAM- 1 and hs- CRP between r = 0.543 , P lt ; 0.01) . Serum IMA, sICAM -1 and hs-CRP levels in AMI , the SAP to exclude the group of the area under the ROC curve is greater than 0.83 and 0.74 , serum IMA, sICAM- 1 and hs-CRP of patients with AMI diagnostic sensitivity and specificity were 0.90 0.80,0.75,0.85 and 0.80,0.77 , exclude SAP patient diagnostic sensitivity and specificity were 0.85,0.95,0.60,0.75 and 0.70,0.90 SAP patients to exclude the diagnosis of misjudgment rate of 0.05, 0.25 and 0.10 , respectively . Conclusions Serum IMA, sICAM -1 and hs-CRP levels in AMI diagnosis of CHD exclusion have a certain reference value , can improve the diagnostic accuracy and sensitivity , its elevated level can be used as the corresponding disease severity and prognosis discriminant one of the reference indicators

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