Correlation of type 2 diabetes serum TGF-β1 and PDGF-BB levels and urinary albumin excretion rate in patients with kidney disease
|Keywords||Transforming growth factor-β1 platelet derived growth factor-BB diabetic nephropathy urinary albumin excretion rate Type 2 diabetes mellitus|
Objective To investigate the relationship between the levels of Transforming growth factor-betal(TGF-β1) and Platelet derived growth factor-BB(PDGF-BB) in serum and urinary albumin excretion rate in type 2 diabetes mellitus (T2DM), explore the role of TGF-β1 and PDGF-BB in the development of diabetic nephropathy.Method The subjects were 120 cases. One healthy control group (NC, UAER <20μg/min) 60 cases,90 cases of type 2 diabetic patients were divided into normal albuminuria group (NA, UAER<20μg/min), microalbuminuria group (MA, UAER 20～200μg/min), macroalbuminuria group (ODN, UAER> 200μg/min) of the 30 cases, measured blood pressure (SBP/DBP), body mass index (BMI), fasting blood glucose (FPG), Fasting C peptide (FCP), glycosylated hemoglobin (HbA1c), albumin excretion rate (UAER), TGF-β1, PDGF-BB levels.Results NC, NA, MA, ODN TGF-β1 levels in serum gradually increased, type 2 DM patients in each group of serum TGF-β1 were significantly higher than that of NC group (Sig=0.000～0.037, P<0.05), ODN was significantly higher than NA group and MA group (Sig=0.000, P<0.05), NA group and MA group showed no significant (Sig= 0.468, P>0.05). Type 2 DM patients in each group of serum PDGF-BB were significantly higher than that of NC group (Sig=0.000, P<0.05), MA was significantly higher than that of NC group and the NA group (Sig=0.000, P<0.05), but the ODN Group and the NA group and MA group showed no significant (Sig=0.106～0.258, P>0.05). All objects of serum TGF-β1 and PDGF-BB level and duration, BMI, SBP, DBP, FBG, FCP, HbAlc, BUN, Cr, and UAER was positively correlated (r=0.075～0.798, P<0.01); and FCP negative Correlation (r=-0.602～-0.818, P<0.01); TGF-β1 and PDGF-BB level was positively correlated (r=0.470, P<0.01).Conclusions Mediated by TGF-β1 throughout the DN of the lesions, PDGF-BB in the early pathogenic role of DN is particularly significant, both in different stages of DN development of synergies, increased DN progress.