Dissertation
Dissertation > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Uterine tumors

Relation of HPV Infection and TERC Gene Enlargement with Cervical Cancer and Cervical Intraepithelial Neoplasm

Author XiaYan
Tutor ZhangChaoXia
School Xinjiang Medical University
Course Clinical Laboratory Science
Keywords HPV TERC gene Cervical Cancer Cervical precancerous lesions
CLC R737.33
Type Master's thesis
Year 2009
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Objective: To investigate the relationship between HPV infection and TERC gene amplification with cervical cancer and cervical precancerous lesions of . Methods: The flow-through hybridization method detected 26 cases of cervical cancer , 31 cases of cervical precancerous lesions , and 56 normal controls of HPV infection ; using fluorescence in situ hybridization method of the 113 cases subjects TERC gene amplification detection . The results : (1 ) HPV infection positive rate in the control group was 8.9% , cervical precancerous lesions group was 61.3% and cervical cancer group was 80.8% , among the three groups of HPV infection positive rate difference was statistically significant ( P <0.05 ) cervical precancerous lesions of HPV infection and cervical cancer group were significantly higher than normal control group ( P < 0.0167 ) , and cervical precancerous lesions and cervical cancer group difference was not statistically significant ( P > 0.0167 ) positive rate of HPV infection , HPV infection were 16.150 times the risk of cervical precancerous lesions is negative HPV infection occurs , OR = 16.150, OR95% CI (5.019,51.969), HPV infection were cervical cancer risk of HPV infection negative 42.840 times , OR = 42.840 , OR95 % CI ( 11.221,163.561 to ) ; ( 2 ) TERC gene amplification positive rate of 5.4% in the control group , cervical precancerous lesions group was 54.8% and cervical cancer group was 88.5% , among the three groups TERC gene amplification The positive rate difference was statistically significant (P <0.05), TERC gene amplification of cervical precancerous lesions and cervical cancer group were significantly higher than normal control group ( P < 0.0167 ) , and cervical cancer group TERC gene amplification positive rate the positive cervical cancer risk of precancerous lesions in cervical precancerous lesions group ( P < 0.0167 ) , TERC gene amplification of TERC gene amplification negative 21.452 times , OR = 21.452, OR95% CI (5.498,83.697), TERC gene amplification TERC gene amplification negative 135.444 times increase positive cervical cancer risk , OR = 135.444, OR95% CI (25.409,721.998). Conclusion : ( 1 ) HPV infection and cervical cancer and cervical precancerous lesions and HPV infections are risk factors for cervical cancer and cervical precancerous lesions ; (2) TERC gene amplification with cervical cancer and cervical precancerous lesions .

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