Dissertation
Dissertation > Medicine, health > Neurology and psychiatry > Psychiatry > Physical diseases with mental disorders

A Randomized Controlled Observation of Paroxetine in Treating Depression State Patients with Chronic Degenerative Arthritic Pains

Author XuJun
Tutor ZhuWanEr
School Zhejiang University
Course Psychiatry and Mental Health
Keywords Chronic Chronic degenerative joint pain Depressive disorder Paroxetine
CLC R749.2
Type Master's thesis
Year 2009
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Background: Pain, especially chronic pain, is not simply the physiology feeling, but also the complex emotional performance psychology, this complex physiological and psychological reaction, is always accompanied by emotional reactions, clinical experience has shown that chronic pain and depression are often intertwined in together, can be aggravated or even caused by the occurrence of depression. Research purpose of this study need to explore the spirit of the relationship between psychological factors and chronic pain and clinical efficacy of paroxetine (Seroxat) combined depressive state of chronic degenerative joint pain. Research Methods 228 patients with chronic degenerative joint pain in patients with depressive symptoms Zung's self-rating scale (SDS) rated screened depressive state, in the treatment of pain plus piece of paroxetine (Seroxat), observed its pain visual analog scale (VAS) score, Zung's self-rating scale of depressive symptoms (SDS) score and life satisfaction score and clinical efficacy evaluation. Results Zung's self-rating scale of depressive symptoms (SDS) standard score = 53 for depression. The survey SDS = 53 the number of people together, there were 71 cases. The proportion was 33.1% (71/228). 71 cases rule out pregnancy or breast-feeding: depression secondary to other diseases; are other antidepressants governance; serious heart, liver and kidney dysfunction; organic brain disease and epilepsy; with serious patients with suicide attempts, aggressive behavior, hallucinations, paranoia and other symptoms in patients with and into treatment research final results for the 61 cases. 3, 61 patients according to the random number table, were randomly divided into a control group and the paroxetine group, were treated. After treatment, the paroxetine group and the control group Zung's self-rating scale of depressive symptoms (SDS) score, life satisfaction score and pain visual analog score (VAS), significantly lower than before treatment (P <0.05); but treatment score of 4 and 6 weeks after the paroxetine group Zung's self-rating scale of depressive symptoms (SDS), life satisfaction score and pain visual analog score (VAS), the degree of improvement was significantly better than the control group (P <0.05). 4, the control group and the paroxetine group were in the sixth week the overall evaluation of clinical efficacy. Paroxetine group, the total efficiency (cure rate significantly effective and efficient) of 86.67%, the control group, the total effective rate of 58.06%. Paroxetine group than the control group (P <0.05). The research conclusions chronic pain associated with psychological factors of depression in patients with antidepressant therapy can significantly improve both mental and physical symptoms.

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