Dissertation > Medicine, health > Obstetrics and Gynaecology > Obstetrics > Pathological pregnancy ( abnormal pregnancy )

The Analysis of Serum Adiponectin and Visfatin Levels in Pregnancy with Different Glucose Tolerance and the Effect on the Secretary Function of Beta Cell

Author LeiChen
Tutor ZhangRuYi;ZhouXu
School Ningxia Medical University
Course Endocrine
Keywords Different glucose tolerance Gestational diabetes Serum adiponectin Visfatin β-cell function
CLC R714.2
Type Master's thesis
Year 2009
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Objective pregnancy in different glucose tolerance status individuals by adiponectin (ADPN) Determination of visfatin and related factors study to explore pregnancy in different glucose tolerance status individuals ADPN and visfatin levels change as well ADPN visfatin in gestational diabetes (GDM) in islet β-cell function and possible mechanisms in the pathogenesis of GDM. GDM diagnostic criteria and different glucose tolerance groups: divided into the GDM group (33 cases), gestational impaired glucose tolerance (GIGT) group (n = 33) and normal pregnancy (NGT) group (30 cases). Serum ADPN (ELISA method), visfatin (ELISA), and fasting and postprandial blood glucose, HbAlc, blood lipid levels, fasting and postprandial insulin, fasting and postprandial C-peptide, endocrine hormones (thyroid hormone, progesterone differences, estradiol, blood PRL) indicators were compared between groups and correlation analysis. 1) different glucose tolerance status an individual's overall fat and thigh subcutaneous fat area (FA) of pregnancy no difference; significantly increased with glucose tolerance injury severity, abdominal visceral fat area (VA) and abdominal subcutaneous fat area (SA) , P lt; 0.05. 2) GDM, GIGT group fasting and postprandial insulin, C-peptide was significantly higher, the GDM postprandial insulin and C-peptide was significantly higher than GIGT, P lt; 0.05) impaired glucose tolerance in pregnancy individual pregnant hormone and prolactin secretion increased significantly, but no significant increase in free thyroxine. The GDM free iodine thyroid thyroxine than GIGT patients. 4) compared with the NGT group, GDM, serum ADPN GIGT group decreased significantly, P lt; 0.05; the GDM group serum ADPN than GIGT group, P lt; 0.05 5) GDM is significantly higher fasting and postprandial serum visfatin of at GIGT and NGT GIGT with NGT no difference; each group of factors no significant difference in fasting and postprandial serum lipid. 6) ADPN not change with the progress of the gestational age, serum visfatin did not change in the second trimester, but was significantly higher in the third trimester. 7) stepwise multiple regression analysis: BMI, VA, SA, 2hPG of FINS, 2-hour postprandial insulin, fasting C-peptide, postprandial C-peptide, HOMA-IR and is closely related to ADPN level; while BMI, FPG 1hPG, 2hPG, 3hPG, FINS, fasting C-peptide, VA, SA and the serum visfatin closely related. 8) ADPN was and of HbA1c, FPG, 1hPG 2hPG 3hPG was being related, with BMI, age, HDL, VA was negatively correlated; the the the serum visfatin AND FPG, 1hPG, 2hPG 3hPG FINS fasting C-peptide, HOMA-IR , VA, SA positive correlation was negatively correlated with ISI. Conclusion glucose tolerance injury pregnancy individual exists not only delay due to insulin resistance caused by the massive release of insulin, but also the presence of insulin release. Serum visfatin change with gestational age changes in the process of pregnancy progress. The secretion increase of ADPN can promote islet beta cells to secrete insulin, serum visfatin stimulation by blood sugar can increase the secretion of insulin, visfatin also can affect insulin secretion, and jointly play a lower blood sugar role.

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