Experimental Studying on Decoction of Xuanfuhua-Kudouzi in Preventing and Treating Hepatic Fibrosis
|School||Xinjiang Medical University|
|Course||Traditional Medical Formulae|
|Keywords||Xuanfuhua Kudouzi HejI Hepatic fibrosis CCL 4|
Objective:Xuanfuhua Tang is from Jingui Yaolue(Synopsis of Prescriptions of the Golden Cabinet),which is composed of Xuanfuhua,Qiancao,Congjin. It can promote the circulation of qi , activate blood circulation, and activate yang to remove stagnation. Nowadays, we can see that in clinical practice, Xuanfuhua Tang already far exceeded the range of liver diseases used for in ancient times. Even more, the prescription is now widely used in internal medicine and gynecological. The development of experimental research probes into the mechanisms that are the base for clinical treatment in many ways. From experimental research, we can see that the prescription can prevent and treat hepatic fibrosis. Kudouzi is xinjiang local herb bearing resourceful, which has anti-algesic effect, anti-virus effect, and also regulates immunity functions, prevent and treat hepatic fibrosis. To study the action of experimental study of Xuanfuhua Kdouzi Heji to prevent and treat hepatic fibrosis in mice.Methods: The mice in control group were treated by daily oral gavage with vehicle. The mice in other four groups were given SC injection of 40% CCL 4 10ml?kg-1 35d and treated by either daily oral gavage with vehicle, Xuanfuhua Tang ,Kudouzi Jianji, Xuanfuhua Kdouzi HejI for 42d. Histological examination was examined. The serum hyaluronic acid and ALT were observed. Results: Xuanfuhua Tang ,Kudouzi Jianji, Xuanfuhua Kdouzi HejI can relieved liver injury, they can decreased HA and ALT. There are not different with Xuanfuhua Tang ,Kudouzi Jianji, Xuanfuhua Kdouzi HejI.Conclusion: Xuanfuhua Kudouzi HejI can prevent and treat hepatic fibrosis.