Preliminary Study of CoenzymeQ₁₀ on Renal Protection to Avian Gout

Avian gout is a common disease in many parts of the world.The foreign statistics shows mortality of gout reaches about 16%-50% and avian gout has a higher mortality rate. These years, there is a growing trend of occurrence of Avian gout. Because of feed prduction and feeding management which have many predisposing factors exist in intensive farming of chickens, especially the instable source of feed lead to a higher calcium and protein content which cause younge layers have a common cases of gout. Avian gout has no specific treament recently, so comprehensive prevention comes first. Thourgh artificial reproduction of gout cases in the paper, we add Coenzyme Q10 with cases for studying preliminary its protective effect on the body and provide a theoretical basis for cinical prevention and treatment.1 The study of clinical pathology with Coenzyme Q10 on Avian gout bodyOne hundred and twenty 1 day of age, healthy grows were randomly divided into four groups and the supplemental dosages of Coenzyme Q10 were 0,0,20,40 mg/kg respectively, the initial ages was 1 day wihin 6 weeks.Each group were fed with normal calcium and crude protein diet (1.14% calcium,17.62% crude protein) at first 30 days. The control group were fed with normal calcium and crude protein diet (1.14% calcium,17.62% crude protein), other groups were fed with high calcium and high protein diet at secend 30 days (3.85% calcium,28.73% crude protein). At the day 0,8,16,24 days after feedind the high calcium and high protein diet, we seperated serum and did a dynamic measurement to the serum Uric acid, Creatinine, Blood urea nitrongen, magnerium, sodium, chlorine, calcium, Inorganic P. At the end of the experiment,6 growers in each group were dissected, and kidney sampled and observed by optical microscope. The result showed serum Uric acid, Creatinine, Blood urea nitrongen decreased significantly when adding Coenzyme Q10. Comparing to 80mg/kg CoQ10, the dosage of 40mg/kg CoQ10 made serum Uric acid, Creatinine, Blood urea nitrongen decreased significantly. The tubular and glomerular of the two groups which feed CoQ10 had lighter lesions than the other group without feeding CoQ10 and the lighter lesions showed that edema of renal tubular epithelial cells were alleviated, the number of inflammation cell reduced and the structure of renal tubular and glomerular became clear.2 Effects of Coenzyme Q10 on antioxidant ability to Avian goutOne hundred and twenty 1 day of age, healthy grows were randomly divided into four groups and the supplemental dosages of Coenzyme Q10 were 0,0,20,40 mg/kg respectively, the initial ages was 1 day wihin 6 weeks.Each group were fed with normal calcium and crude protein diet (1.14% calcium,17.62% crude protein) at first 30 days. The control group were fed with normal calcium and crude protein diet (1.14% calcium,17.62% crude protein), other groups were fed with high calcium and high protein diet at secend 30 days (3.85% calcium,28.73% crude protein). The result showed serum SOD, GSH-Px, T-AOC increased significantly when adding Coenzyme Q10. Comparing to 80mg/kg CoQ10, the dosage of 40mg/kg CoQ10 made SOD, GSH-Px increased significantly and it could increase T-AOC relatively without a significant difference. The resuts indicated that feeding CoQio in relative long term can improve the body’s antioxidant capacity.3 Effects of Coenzyme Q10 on body immunological function to Avian goutOne hundred and twenty 1 day of age, healthy grows were randomly divided into four groups and the supplemental dosages of Coenzyme Q10 were 0,0,20,40 mg/kg respectively, the initial ages was 1 day wihin 6 weeks.Each group were fed with normal calcium and crude protein diet (1.14% calcium,17.62% crude protein) at first 30 days. The control group were fed with normal calcium and crude protein diet (1.14% calcium,17.62% crude protein), other groups were fed with high calcium and high protein diet at secend 30 days (3.85% calcium,28.73% crude protein). The result showed thymus, spleen and busal index increased significantly and lymphocyte proliferation was stimulated when adding Coenzyme Q10. Comparing to 80mg/kg CoQ10, the dosage of 40mg/kg CoQ10 made thymus and busal index increased significantly. The resuts indicated that feeding CoQ10 in relative long term can improve the body’s immune capacity.