Dissertation > Medicine, health > Pharmacy > Pharmacology > Experimental Pharmacology

Experimental Research of the Protective Effect on Renal Function of Sivelestal during Cardiopulmonary Bypass

Author LiuYanPing
Tutor ZhangHong
School Zunyi Medical College,
Course Anesthesiology
Keywords Cardiopulmonary bypass Sivelestat sodium C5b-9 Elastase
CLC R965
Type Master's thesis
Year 2010
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Objective concept Cha Xiwei to Secretary of sodium CPB cardiopulmonary bypass (CPB) during plasma elastase (NE), urine concentration of C5b-9 the kidney morphology changes , explore its protective effect on the kidneys . 12 healthy adult dogs were randomly divided into control group ( group C , n = 6 ) and carbaryl Secretary sodium group (S , n = 6 ) , the establishment of a canine CPB model , the two groups were in transit (T1) , blocking the ascending aorta 15 min ( T2), 45 min (T3) , open 15 min (T4), open 60min (T5) venous blood , T1, T3 , T5 point in time to take urine . Venous blood after centrifugation measured plasma NE, urine measured C5b- 9 ; observe the morphological changes T5 when to take the right kidney slices . Results ① CPB , the two groups of animals at each time point plasma NE and urinary C5b-9 levels were significantly higher than before CPB . Point group comparison at each time point after the S group CPB plasma NE and urinary C5b-9 levels were lower than in group C ( P <0.05 ) . ② CPB after two groups of animals kidney pathomorphological change , but in varying degrees C group compared to the S group morphological changes to light . Conclusion CPB to apply Sivelestat urine sodium may reduce complement activation by inhibiting the activity of the NE C5b-9 concentration given protective effect on the kidneys in dogs CPB .

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