Dissertation > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Bone diseases > Spine and back disorders > The vertebrae quality hyperplasia

Relationship between Cervical Spondylosis Myelopathe and Serum Levels of VitaminB12 and Folic Acid

Author HuangLiBiao
Tutor ChenWenJun
School Fudan University
Course Orthopedics
Keywords Cervical spondylotic myelopathy Vitamin B12 Folic acid Pathogenesis Correlation
CLC R681.55
Type Master's thesis
Year 2010
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Objective: To understand the cervical spinal cord patients with vitamin B12 and folic acid metabolite levels to explore vitamin B12, folic acid metabolism in the pathogenesis of cervical disease . Methods: 111 cases of clinical patients with cervical spondylotic myelopathy preoperative fasting serum vitamin B12, folic acid value , and then based on the imaging findings , the degree of spinal cord compression , duration of disease , the patient grouping . A case-control study, statistical analysis , and difference . Results: 1) patients with cervical spinal cord of high signal intensity (ISI) serum folic acid , vitamin B12 water on average lower than the high signal group (P lt; 0.05, the difference was statistically significant ) ; 2 ) spinal cord signal distribution and spinal cord pressure degree of correlation between the degree of spinal cord compression mild group and severe group spinal cord high signal appears overall distribution no significantly different ( P gt ; 0.05, the difference was not statistically significant ) ; 3 ) spinal cord without obvious oppression but a high signal group cervical patient serum vitamin B12 levels lower than other groups , spinal cord compression was significantly higher than other groups but there was a high signal levels of serum vitamin B12 levels ; 4 ) in patients with spinal cord high signal group course of a short course of the disease than patients with high signal . Conclusion : Vitamin B12 and folate deficiency a risk factor for cervical spondylotic myelopathy . Plays a complex role in the pathogenesis of cervical spondylosis . Further study of its role in the pathogenesis of cervical disease , for clinical treatment, provide some theoretical basis for the prevention of cervical spondylosis .

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