Dissertation
Dissertation > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Metabolic diseases > Metabolic disorder of purine ( Purine )

Efficacy of cyclooxygenase-2 inhibitors in combination with low dose colchicine treatment of acute gouty arthritis

Author WangKaiHong
Tutor LiChangGui
School Qingdao University
Course Endocrine and metabolic diseases
Keywords gouty arthritis Ankangxin colchicine
CLC R589.7
Type Master's thesis
Year 2011
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Objective :To evaluate the clinical efficacy of Ankangxin (COX-2 inhibitors-etoricoxib tablets) combined with small doses of colchicine for the treatment of acute gouty arthritis.Methods:Ninty patients with acute gout were selected for random parallel controlled trial.These patients were all from the endocrine outpatients clinic of Qingdao University Medical College and Tan Cheng county first people’s hospital, aged 20-75 years old, and were all ruled out with severe hypertension, liver and kidney dysfunction, heart failure, serious gastrointestinal diseases, coagulation disorders and other severe diseases. According to randomized parallel control principle, patients were divided into study group,the control group 1 and the control group 2.Every group includes 30 cases,whose age.duration,patient’scondition was no significant difference (P>0.05).All patients were given Ihe same basic treatment, such as:bed rest;increased limb;low-purine diet; more drinking water, alkalization of urineExcept the basic treatment, the 30 cases in the study group were treated with Ankangxin (etoricoxib tablets) 120mg, once day, combined with small dose of colchicine 0.5mg, three times day, for three days, the patients in the control group 1 were given large dose of colchicine treatment, (3 days in all)-Two tablets of colchicine (1.0mg) were serviced in the first time, and one tablet (0.5mg) was given every 2 hours, once 0.5mg, three times a day, was serviced until the pain reduced largely.All olchicine would not be given if the serious diarrhea, abdominal pain happened. These patients in the control group 2 were treated with Ankangxin (etoricoxib tablets) 120mg, once day.The clinical effectiveness and Ihe incidence of adverse events were objected.Results :No case in study group and the control group 2 was withdrawn from this study ,while four cases in control group 1 were withdrawn. The difference in the decrease of pain and joint swelling scor between the study group and the the control group 1 was not significant (P>0.05), while the difference in the decrease of pain and joint swelling scor between the study group and the the control group 2 was significant (P<0.05).Conclusion :l.The clinical efficacy of Ankangxin combined with small doses of colchicine was the same to the large dose of colchicine on treatment of acute gouty arthritis.However, significant adverse events were detected in study group than the control group.2.The clinical efficacy of Ankangxin combined with small doses of colchicine on treatment of acute gouty arthritis was obvious better than those single Ankangxin treatment.

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