Dissertation
Dissertation > Medicine, health > Pharmacy > Drug basic science > Medicinal Chemistry

Synthesis and Characterization of Two Novel Magnetic Resonance Imaging Contrast Agents

Author YaoYao
Tutor YuKaiChao
School Huazhong University of Science and Technology
Course Organic Chemistry
Keywords Magnetic resonance imaging Contrast agent Biologically sensitive CPPs Indole acetic acid
CLC R914
Type Master's thesis
Year 2011
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Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) in recent years, the rapid development of new technologies of medical imaging , MRI contrast agents is an important part of this technology . Magnetic resonance imaging contrast agents are used to improve the water proton relaxation rate , thereby enhancing the magnetic resonance signals the contrast between normal and diseased tissue of a paramagnetic chemical reagents , wherein the research relaxation performance high, low toxicity , and for certain parts targeting contrast agent has become the major trends in this area . In this paper, the research progress of the biological sensitive MRI contrast agent , and completed the following work : ( 1 ) designed and synthesized by the the targeting function RGD peptide fragments , penetrating feature the polyarginine peptide segment paramagnetic chelate unit consisting of novel MRI the polypeptide contrast agent , and related intermediates and ligand IR, 1H NMR and ESI-MS characterization . Important intermediates of MRI contrast agents ( 2 ) Synthesis of 1, 4, 7 - tris ( tert-butoxycarbonyl methyl ) -10 - (ethyl ) -1 , 4, 7, 10 - tetraazacyclo dodecane and its preparation routes and the experimental conditions were optimized . (3) the product, 1 , 4 , 7 - tris ( tert-butoxycarbonyl methyl) -1 , 4 , 7 , 10 - tetraaza cyclododecane hydrobromide synthesis method is improved , not only easy to operate , and the value of the yield is higher than the literature values ??. (4) linked to the indole acetic acid the paramagnetic chelate unit has an important influence on plant growth , the design and synthesis of a MRI contrast agent used in the study of plant growth , and related intermediates and ligand 1H-NMR, ESI-MS characterization.

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