Dissertation > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues

Neural Mechanisms of Motor Function with Structural Equation Modeling in Stroke Study

Author WangXiaoJun
Tutor LiZuo
School Huazhong University of Science and Technology
Course Pattern Recognition and Intelligent Systems
Keywords fMRI Stroke Neuroplasticity Rehabilitation ICA SEM
CLC R318.0
Type Master's thesis
Year 2011
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It’s well known that the brain is the most complicated and perfect dynamic information processing system. In a sense, the brain can be considered as a multi-layered dynamic distributed network. In order to execute a series of complex functions, it can establish and reestablish its functional connections incessantly.This paper uses block design method as experimental method to obtain functional magnetic resonance imaging data from healthy individuals and stroke patients, and uses SPM for fMRI data pre-processing. Describes the data-driven and model-driven data processing method, and also describes the independent component analysis in detail, including its principle and its realization process. Using group ICA to analysis of the fMRI data of hand movement, and select the movement-related regions of interest, obtain the corresponding time series of region of interest. This thesis studies structural equation modeling in depth, and modeling model for the selected time series with SEM, obtaining the related motor cortex network model about the department of stroke patients and health staff hand movement. By comparing healthy people and patients models, analyzes the neural mechanisms changes of motor function after stroke, and studies the neural network changes about the left/right hand movements and between the complex movement and voluntary movement. By comparing healthy people left and right hand movements, it found that in addition to the contralateral motor cortex and ipsilateral cerebellum activation, may also be associated with activation of the ipsilateral cerebral cortex, often confined to the ipsilateral M1, SMA region, which may be left-handed non- symmetry activation; Ipsilateral movement of patients, no significant activation of the relevant supplementary motor area (SMA), it can be inferred that the activity of SMA regional is very important for the people’s autonomy exercise ability; Ipsilateral movement of patients, except that the contralateral M1 area has obvious activated, there are a lot of ipsilateral related cortical areas activation (such as M1 or sensory cortex). The results indicated that the district on behalf of the brain function has changed, the motor cortex effective network is reconstructed to realize functional reorganization and self-repair, which is a full expression of brain plasticity.

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