Dissertation
Dissertation > Medicine, health > Clinical > Diagnostics > Diagnostic Imaging > Magnetic resonance imaging

The Comparative Study and Clinical Application of Low-strength Mr Multiple Fat-suppression Sequences Imaging on the Knee

Author HuLiangBo
Tutor ZhaoJianNong
School Chongqing Medical University
Course Medical Imaging and Nuclear Medicine
Keywords knee MRI fat-suppression sequences parameters optimization
CLC R445.2
Type Master's thesis
Year 2010
Downloads 47
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PART ONE COMPARATIVE STUDY OF LOW-STRENGTH MR MULTIPLE FAT-SUPPRESSION SEQUENCES IMAGING ON THE KNEEPurpose: A group of cases were performed with low-strength magnetic resonance imaging (MRI) multiple fat-suppression sequences to explore the best magnetic resonance (MR) sequence showing articular cartilage,the meniscus and the synovial membrane in the knee.Materials and MethodsSubjects20 cases with knee joint diseases were selected for low-strength MRI the fat-suppression sequences study of the articular cartilage,the meniscus and the synovial membrane in their knees, including 9 cases male and 11 cases female.MR scanning All images were acquired with a 0.3T imaging unit (Hitachi AIRIS-Ⅱ). After routine MR sequence scanning, sagittal imaging were performed with FatSepG-WFT2* sequence, FatSepF-WFT2 sequence and FIR-STIR sequence.MR images analysisAll the images were co-checked by two radiologists. In the MR workstation,the signal intensity of the articular cartilage,the meniscus and the synovial membrane and background were measured in FatSepG-WFT2* sequence, FatSepF-WFT2 sequence and FIR-STIR sequence, respectively The area of region of interest(ROI) was about 4mm2. The Signal-to-noise ratio (SNR) for cartilage, meniscus , synovial membrane,subcartilage bone tissue and fluid were calculated, respectively.Then contrast-to-noise ratio (CNR) of surrounding the articular cartilage, the meniscus and the synovial membrane to the surrounding tissues was also acquired.Statistical analysisAll the data were expressed as Meanf SD and statistical software SPSS 13.0 was used. One-way ANOVA was used to evaluate the differences of SNR and CNR between the different MR sequences in cartilage, meniscus, synovial membrane,subcartilage bone tissue and fluid. If equal variances assumed,Least-significant Difference (LSD) test was applied, otherwise Kruskal-Wallis test or/and Dunnett’s T3 test was used. P<0.05 was considered to indicate significant difference.Results1. Analysis of SNR for the articular cartilage in the knee and its sunrounding tissues SNR values of cartilage, meniscus ,synovial membrane and fluid were significant different among three MR sequences, including FatSepG-WFT2* sequence, FatSepF-WFT2 sequence and FIR-STIR sequence (P=0.000). There was significant difference in SNR of cartilage between FatSepF-WFT2 sequence and FIR-STIR sequence(P=0.022), others (P=0.000). There was significant difference in SNR of meniscus between FatSepF-WFT2 sequence and FIR-STIR sequence(P=0.133), others (P=0.000). There was significant difference in SNR of synovial membrane between FatSepF-WFT2 sequence and FIR-STIR sequence(P=0.001).others (p=0.000). There was significant difference in SNR of fluid between FatSepF-WFT2 sequence and FatSepG-WFT2* sequence(P=0.015).others (p=0.000).SNR values of subcartilage bone,were significant different among three MR sequences, including FatSepF-WFT2 sequence and FIR-STIR sequence ,with Krustal-wallistest (P=0.049).2.Analysis of CNR for the articular cartilage, meniscus and synovial membrane in the knee and theirs surrounding TissuesSignificant differences of the CNR as for cartilage to subcartilage bone, and cartilage to fluid, meniscus to fluid, synovial membrane to cartilage and synovial membrane to fluid could be found among the three sequences (P<0.05). Except for those between FatSepG-WFT2* sequence and FIR-STIR sequence as for meniscus to fluid and synovial membrane to fluid, and between FatSepF-WFT2 sequence and FIR-STIR sequence as for synovial membrane to cartilage (P>0.05), others were obviously different (P<0.05) in CNR. There were obviously different of the CNR as for meniscus to synovial membrane with One-way ANOVA(P<0.05), others were no obviously different (P>0.05)Conclusion:Among the three sequences including FatSepG-WFT2* sequence, and FIR-STIR sequence. The FatSepG-WFT2* sequence was the best sequence of showing articular cartilage and meniscus. The synovial membrane and fluid were shown as high signal intensity FatSepF-WFT2 sequence And FIR-STIR sequence was the best to show the myeloid. PART TWO THE KNEE JOINT COMMON DISEASE EVALUATED WITH MULTIPLE MR FAT-SUPPRESSION SEQUENCES IMAGINGPurpose:A group of the knee joint common disease were performed with low-strength MRI multiple fat-suppression sequences to explore the best magnetic resonance (MR) sequence showing the knee.Materials and MethodsSubjects: 25 cases of the knee joint common disease were selected for low-strength MRI the the fat-suppression sequences study of the articular cartilage,the meniscus and the synovial membrane in their knees, including 9 cases male and 16 cases female. The patients were 17-87 years old, average 56; left knee were 11,right knee were 14.MR scanning: All images were acquired with a 0.3T imaging unit (Hitachi AIRIS-Ⅱ). After routine MR sequence scanning, sagittal imaging were performed with FatSepG-WFT2* sequence, FatSepF-WFT2 sequence and FIR-STIR sequence.MR images analysis: All the images were co-checked by two radiologists on the same diagnostic code and the last diagnosis. All images were confirmed by arthroscopy or operation.Statistical analysis: All the data were expressed as Meanf SD and statistical software SPSS 13.0 was used.χ2 test was used. P<0.05 was considered to indicate significant difference.Results: The results of arthroscopy or operation use as gold criterion。In menisci injuries,the accuracies in- FatSepG-WFT2* sequence, FatSepF-WFT2 sequence and FIR-STIR sequence were respectively 90.00%,60.00%,68.00%. FatSepG-WFT2* sequence was superior to other sequences and weighted images (p<0.05) withχ2 test. In articular cartilage injuries,the accuracies were respectively 90.67%,78.67%,80.00%。FatSepG-WFT2* sequence was superior to other sequences and weighted images (p<0.05) withχ2 test. In posterior synovial membrane disease,the accuracies were respectively 78.67%,92.00%,81.33%. FatSepF-WFT2 sequence was superior to other sequences and weighted images (p<0.05) withχ2 test.Conclusion: The FatSepG-WFT2* sequence was the best sequence of showing the articular cartilage injuries and the meniscus injuries. The synovial membrane disease were shown as high signal intensity FatSepF-WFT2 sequence.

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