Synthesis and Biology Activity Study of Triazole-thioacetic Hydrazone and Acetamides Derivatives
|School||Northwest Normal University|
|Keywords||Triazole-thioacetic hydrazone Derivatives supramolecular crystalstructure microwave irradiation bioactivity|
This thesis includes three chapters.Chapter 1: A brief review for the research, synthetic methods and applicationvalues of 1,2,4-triazole derivatives and the hydrazones derivitives in recent years.Chapter 2: Synthesis and biology activity of intermediate 1,2,4-triazolehydrazone derivitives .A series of hyrazones derivatidves have been synthesized by condensationreaction of 2-[3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio]acetyl hydrazideswith various substituted aromatic aldehydes or dialdehydes under the microwaveirradiation, compared with classic methods, this method has the advantages of quick,high-yield, clean and work-up easily, all of the compounds have been characterizedby 1H NMR, 13C NMR, IR spectra and elemental analyses. The preliminary biologicaltests showed that some of the title compounds remarkably enhanced the rootelongation in the whole range of concentrations. Morever, the title compound 4m wasbrought up to crystal. The crystal structure was determined by X-ray diffractionanalysis, and the result show that the familiar supramolecular weak forces wereinvolved in the crystal, just as the intermolecular hydrogen bond interactions, whichlink the molecules together as a tri-dimensional netlike supramolecular.Chapter 3: Synthesis and biology activity of 1,2,4-triazole-thioacetic acetamidesDerivativesA series of new 2-（4-phenyl-3-phenoxymethyl-4H-1,2,4-triazole-5-ylsulfanyl）-acetamides were synthesized by the reaction of S-alkylation from chloroacetamidereacting with some triazole derivatives in ethanol media without catalysis. Thestructures of all synthesized compounds were confirmed by elemental analysis, IR and1H NMR. The preliminary biological tests showed that some of the title compoundsremarkably enhanced the root elongation in the low concentrations.