Dissertation
Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology

Studies on the Synthesis and Antioxidant Activity of Novel Curcumin Analogues

Author WangShuZuo
Tutor SunGangChun
School Henan University of Technology
Course Organic Chemistry
Keywords Curcumin analogs Synthesis DPPH Antioxidant
CLC R285
Type Master's thesis
Year 2010
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Curcumin is an orange - yellow powder , mainly extracted from turmeric genus , with important food and medicinal value . Years of studies have shown that curcumin has anti-cancer , anti-inflammatory , anti-oxidation, anti-Alzheimer 's disease , anti-HIV and other pharmacological effects . The most prominent characteristics of curcumin showed strong antioxidant capacity . In order to more effectively play its medicinal value , in -depth understanding of their structure-activity relationship based on design and synthesis of a series of curcumin analogs measured antioxidant activity using DPPH method . The experiment first synthesis of complexes of acetylacetone and boron oxide with ethyl acetate as a solvent , n-butylamine as catalyst , indolyl aldehyde with the complex through a Claisen-Schmidt reaction synthesis of curcumin analogues A1 , A2, A3 ; through the introduction of the water - soluble group in curcumin ( A0 ) on the molecule , the synthesis of a curcumin derivative B1 ; to hexahydropyrido catalyst , ethylene glycol as a solvent , Synthesis of C1 , C2, C3 , C4 , C6, C7, C8, C9, C10, C11, C12, D1, D2; with 30% sodium hydroxide solution as a catalyst, methanol and water as solvent , synthetic C5 . The experiment also explored the solvent , catalyst Claisen-Schmidt reaction process of synthetic A1 orthogonal experiment method to improve the post-processing . The experiments also compare the two methods of synthesis of C3 . Synthetic products by UV , IR , NMR , mass spectrometry confirmed . Experimental Application DPPH method , were measured at five different concentrations of the radical scavenging rate , the results showed that each product have a certain antioxidant activity , radical scavenging rate is increased with time , but also with the increased product concentration increases. Wherein the product A2 , C8, C9 antioxidant activity is most significant .

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