Relationship between Level of Serum Uric Acid and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus
|School||Zunyi Medical College,|
|Keywords||Type 2 diabetes mellitus Lower extremity arterial disease Ankle brachial index Serum uric acid|
Objective:To explore the relation that level of serum uric acid (SUA) and lower extremity arterial disease (LEAD) in patients with type 2 diabetes mellitus (T2DM), serum uric acid was measured in T2DM patients.Methods:Eigthy-two cases with type 2 diabetes mellitus at Endocrinology Department in our hospital were recruited. Height, weight were measured to calculate Body Mass Index(BMI) and blood pressure was measured; serum uric acid, serum urea, serum creatinine, plasma glucose, glycosylated hemoglobinAlc (HbAlc), connecting peptide, blood lipids, microalbuminuria (MAU) were measured; ankle brachial index(ABI)was used as diagnostic criteria to determine the presence of LEAD. Research objects were divided into two groups by with or without LEAD, LEAD group (27cases) and Non-LEAD group (55 cases). Related clinical indicators and chronic diabetic complications between tow groups were statistically analyzed.Results:(1) Serum uric acid level (426.15±72.75) of LEAD group was obviously higher than that (331.71±68.67) of none LEDA group (P< 0.05). (2) Prevalence rate of HUA in T2DM patients with LEAD was significantly higher than that of none LEAD (P< 0.05). (3) After getting rid of confounding factors, multi-factor logistic stepwise regression analysis showed that serum uric acid was associated with LEAD (P<0.05).Conclusions:With increased serum uric acid level, incidence of LEAD in patients with type 2 diabetes mellitus was higher. Serum uric acid was close related with LEAD, and serum uric acid was independent risk factor for LEAD.