Dissertation
Dissertation > Medicine, health > Pharmacy > Pharmacy > Pharmaceutics

Galactosylated Chitosan Grafted Polycarprolactone Nanoparticles Used as Liver Drug Delivery

Author ZuoXiaoLi
Tutor WanYing
School Huazhong University of Science and Technology
Course Biochemistry and Molecular Biology
Keywords galactose amphiphilic nanoparticles curcumin hydrophobic
CLC R943
Type Master's thesis
Year 2010
Downloads 63
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In this thesis, galactose moiety used as the hapatocellular carcinoma cells (HepG2) anchorage was covalently coupled with chitosan derivatives, chitosan-g-polycaprolactone copolymers (CS-g-PCL). In particular, cationic CS-g-PCL copolymers were synthesized with a facile one-pot manner via ring-opening polymerization ofε-CL onto the hydroxyl groups of chitosan by using methanesulfonic acid as solvent and catalyst. The resultant brush-like copolymers, galactosylated chitosan-g-polycaprolactone (Gal-CS-g-PCL), were used to fabricate nano-particles loaded with curcumin, in order to deliver curcumin towards to hapatocellular carcinoma cells in a targeted and sustained manner. And water-insoluble antitumor drug, curcumin, was easily encapsulated into Gal-CS-g-PCL nanoparticles. It was found that most Gal-CS-g-PCL nanoparticles showed well-defined spherical morphologies with narrow particles-size distributions ranging from around 150nm to 350nm and the drug encapsulation efficiency (EE) and drug loading (DL)of the nanoparticles increased from 64.3% to 84.6% and 6.43% to 8.66%, respectively, whereas their accumulative drug release showed a tendency increase due to the enhanced hydrophobic interaction between hydrophobic drug and hydrophobic PCL segments in Gal-CS-g-PCL. Besides, Gal-CS-g-PCL nanoparticles loaded-curcumin showed much higher toxicity as compared to blank Gal-CS-g-PCL particles. The results suggested the potential utilization of curcumin-loaded Gal-CS-g-PCL nanoparticles as carriers of hydrophobic drugs with the improving the delivery and release properties.

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