Study on the Association of Hemorrhagic Transformation after Acute Ischemic Stroke and the Fasting Blood Lipid
|School||Guangxi Medical University|
|Keywords||hemorrhagic transformation after acute ischemic stroke risk factors total cholesterol low-density lipoprotein cholesterol logistic regression analysis|
Purpose Discuss the association of hemorrhagic transformation(HT)after acute ischemic stroke and the fasting blood lipid.Methods Consecutive patients admitted to the First Affiliated Hospital to GuangXi Medical University with objectively diagnosed acute ischemic stroke between 1 January 2009 and 31 December 2010 were included in this retrospective study. HT was evaluated through CT or MRI. Baseline demographic and clinical information was collected at admission including gender, age at onset, past history, systolic blood pressure and diastolic blood pressure levels at admission, blood glucose level, levels of total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C), National Institute of Health Stroke Scale (NIHSS) score at admission, etiology, size and location of stroke. Logistic regression analysis was used to examine the association between HT and the above factors. And Cochran Armitage trend test was used to evaluate the differences of the incidence of HT of groups which were divided into according to all of the patients’fasting blood lipid.Results Lower TC level was related to an increased HT after ischemic stroke, with the risk of HT increasing by 35.6% for each 1-mmol/L decrease in the TC level (OR,0.644 per 1-mmol/L increase; 95% CI,0.456-0.908;P =0.012).When patients were divided into 3 groups according to their TC levels, the incidence of HT was significantly elevated.Conclusions Low level of TC is associated with greater risk hemorrhagic transformation after acute ischemic stroke.