Dissertation
Dissertation > Medicine, health > Oncology > Respiratory system tumors > Lung tumors

Preoperative lung cancer patients in clinical studies of hyperbaric oxygen therapy

Author ZhuRuiKai
Tutor YuanTianZhu
School Guangxi Medical University
Course Cardiothoracic Surgery
Keywords Hyperbaric oxygen Lung Cancer Rheology Surgical complications Clinical Research
CLC R734.2
Type Master's thesis
Year 2011
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Objective: to have lung cancer after complete resection of non-small cell lung cancer indications (nonsmall-cell lung cancer, NSCLC) in patients with preoperative hyperbaric oxygen (hyperbaric oxygen, HBO) therapy, by detecting whole blood reduced viscosity (high, medium, low-cut), peripheral arterial oxygen saturation (saturation of arterial blood oxygen, Sa0 2 ), arterial oxygen tension around (arterial oxygen partial pressure, Pa0 2 ) explore the preoperative HBO therapy in the perioperative period are likely to improve patient body tissue oxygen supply and whether they may reduce the patient's blood viscosity, is conducive to postoperative recovery, and to observe postoperative hospital stay, postoperative complication rate, expected comprehensive treatment of NSCLC provide a new method. Methods: November 2009 to December 2010 Fourth Affiliated Hospital of Guangxi Medical University complete resection of lung cancer, 42 patients with NSCLC were randomly divided into experimental group and control group 21 cases. The control group underwent routine preoperative and postoperative therapy; experimental group on the basis of conventional therapy before surgery I HBO treatment (treatment day 1, continuous 5d, the treatment pressure is 0.2Mpa, Section 6d surgery). HBO treatment 1d, the two groups before surgery 1d, 3d, respectively, after the first measurement Sa0 2 and Pa0 2 , whole blood reduced viscosity (high, medium and low-cut), Comparison between groups each index corresponding time whether there were significant differences (α = 0.05 to test the level), while comparing postoperative hospital stay, postoperative morbidity without significant difference (α = 0.05 to test the level ). Results: (1) the experimental group and the control group before HBO treatment preoperative PaO 2 , SaO 2 , whole blood reduced viscosity (high, medium and low-cut) showed no statistical significance (P gt; 0.05), comparable. (2) the experimental group after HBO treatment (ie, 1 day before surgery) detection index and the control group compared preoperative detection index, the former PaO 2 was significantly higher than that of the latter PaO 2 (t = 2.993, P lt; 0.05), the former SaO 2 and the latter SaO 2 difference was not statistically significant (t = 1. 392, P gt; 0.05); whole blood reduced viscosity of the experimental group was significantly lower than the control group, whole blood reduced viscosity (t high = -8.592, P high lt; 0.05; t in = -7.557, P in lt; 0.05; t low = -4.922, P low lt; 0.05). (3) the experimental group one day before surgery the PaO 2 , SaO 2 HBO treatment was significantly higher than before the PaO 2 , SaO 2 (P lt; 0.05). (4) the experimental group after HBO treatment (ie, 1 day before surgery) of whole blood reduced viscosity was significantly lower than before treatment HBO whole blood reduced viscosity (t high = 6.628, P high lt; 0.05; t in = 6.398, P in lt; 0.05; t low = 7.492, P low lt; 0.05). (5) the third postoperative day, the experimental group PaO 2 was significantly higher PaO 2 (t = 3.263, P lt; 0.05), the experimental group SaO 2 and the control group SaO 2 no significant difference (t = 1.396, P gt; 0.05); whole blood reduced viscosity of the experimental group was significantly lower than the control group, whole blood reduced viscosity (t high = -5.322, P high lt; 0.05; t in = -4.695, P in lt; 0.05 ; t low = -3.191, P low lt; 0.05). (6) the experimental group postoperative hospital stay (mean 12.62 ± 3.99d) than the control group, postoperative hospital stay (mean 13.33 ± 4.64d) shorter, but the difference was not statistically significant (t = -0.535, P gt; 0.05) ; experimental group, incidence of postoperative complications (14.3%) than the control group incidence of postoperative complications (23.8%) was slightly lower, but the difference was not statistically significant (X 2 = 0.154, P gt ; 0.05). Conclusion: NSCLC patients with preoperative HBO treatment: ① the potential to improve preoperative pulmonary function, surgery may improve patient tolerability and reduce the risk of surgery. ② may reduce blood viscosity (whole blood reduced viscosity), in theory, could prevent or delay the metastatic NSCLC. ③ have shorter postoperative hospital stay and reduce surgical complication rate trend.

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