Dissertation
Dissertation > Medicine, health > Ophthalmology > Eye surgery and surgery > Retinal photocoagulation and laser eye surgery

Effect of Tobradex and Pranopulin Eye Drops on the Postoperative Pain and Tear Film of Flap-free Epi-LASIK

Author HuChangBo
Tutor YuanManHong
School Nanhua University
Course Ophthalmology
Keywords Flap-free Epi-LASIK TobraDex and Putnam Spirit flutter Pain Early vision Tear film
CLC R779.63
Type Master's thesis
Year 2011
Downloads 22
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Objective: To study TobraDex and Putnam flutter Ling (Pranoprofen drops) on to the flap excimer laser subepithelial keratomileusis (Flap-free epipolis laser in-situ keratomileusis, Flap-free Epi-LASIK) postoperative pain, early recovery of visual acuity, corneal epithelial healing, tear film Haze influence. Methods: October 2009 to April 2010 in our hospital Flap-free Epi-LASIK surgery 120 patients 240. Randomly divided into a group (tobradex eyedrops group), group 2 (Putnam flutter spirit and tobradex eyedrops group) and the conventional treatment group (control group), for the three groups of patients after the first 1d, 3d, 5d, 7d, 15d and third 1m, 2m, 3m, 4m, 6m corneal irritation, uncorrected visual acuity, best corrected visual acuity, corneal epithelial healing, intraocular pressure, tear breakup time, Schirmer test, tear fern class test, conjunctival imprint cytology, Haze were compared, parallel computer image analysis and the experimental results were analyzed statistically. Results: 1. Corneal irritation: Postoperative 1d and 3d test group 2 and conventional corneal irritation between treatment group difference was statistically significant (t values ??were 4.31, 2.77, P lt; 0.01), postoperative 1d and 3d Test 1 Test 2 group and corneal irritation difference between the groups was statistically significant (t values ??were 2.56, 2.14, P lt; 0.05), while in the third postoperative 5d 7d difference between the groups was not statistically significant ( P gt; 0.05). 2 corneal epithelial healing: After 1d, experimental group 1, group 2 in all cases with the conventional treatment group had a layer of new epithelial corneal surface coverage; postoperative 3d, experimental group 1, group 2 with the conventional treatment group all cases of corneal epithelial layer by layer healing. After most of the basic healing 5d, 7d most mean healing time difference between the groups was not statistically significant (P gt; 0.05). 3 Vision: Test a group and conventional treatment group were 68% (27 cases of 54) and 70% of patients (28 cases of 56) after 1d, 3d visual inspection can not cope with. The remaining patients after 1d, 3d visual acuity test and test a set of group 2 and the conventional treatment group, the difference was statistically significant (t values ??were 2.90,2.17; 3.71, 2.49, P lt; 0.01); postoperative 5d, 1m, 3m difference between the groups was not statistically significant (P gt; 0.05). 4 IOP: Preoperative IOP in each group differences among the groups was not statistically significant (P gt; 0.05); postoperative IOP were lower than preoperative levels, compared with the preoperative was statistically significant (P lt; 0.05 ), postoperative 1m, 4m, 6m intraocular pressure difference between the groups was not statistically significant (P gt; 0.05). 5 tear breakup time (BUT): After 7d, 1m BUT each group compared with the preoperative difference was statistically significant (P lt; 0.05), postoperative 1m then gradually increased postoperative 6m each group compared with the preoperative the difference was not statistically significant (P gt; 0.05), postoperative 7d, 1m, 3m, 6m difference between groups was not statistically significant (P gt; 0.05). 6 Schirmer test I (Schirmer Ⅰ test): After 7d, 1m each group compared with the preoperative tear secretion decreased compared with the preoperative difference was statistically significant (P lt; 0.05), 1m after tear secretion gradually restored, Postoperative 6m each group compared with the preoperative difference was not statistically significant (P gt; 0.05), postoperative 7d, 1m, 3m, 6m difference between groups was not statistically significant (P gt; 0.05). 7 tear fern test (MFT): postoperative 1m, 3m, 4m, 6m tear fern test each group showed no significant difference (P gt; 0.05). After 1m, 3m, 4m each group compared with the preoperative difference was statistically significant (P lt; 0.05). Postoperative 6m each group compared with the preoperative difference was not statistically significant (P gt; 0.05). 8 conjunctival imprint cytology: Postoperative 1m, 3m, 4m, 6m imprint cytology in each group showed no significant difference (P gt; 0.05); postoperative 1m, 3m, 4m, 6m each group compared with the preoperative difference was statistically significant (P lt; 0.05). 9.Haze: Postoperative 1m 10d to be seen Haze occur after 1m peaked after about 6m gradually reduce or disappear, after 7d, 1m, 3m, 6m difference between groups was not statistically significant (P gt; 0.05). Conclusion: 1.Flap-free Epi-LASIK preoperative and postoperative combined TobraDex and Putnam Spirit flutter can significantly reduce postoperative pain and promote early recovery of visual acuity. 2.Flap-free Epi-LASIK preoperative and postoperative combined TobraDex and Putnam flutter on corneal epithelial healing spirit, intraocular pressure, Haze had no significant effect. 3.Flap-free Epi-LASIK postoperative groups decreased tear film stability, tear bracken fern test samples and conjunctival squamous metaplasia grade level increased; tear film stability, tear secretion, tear fern test, conjunctival imprint cytology at 6 months after surgery and returned to preoperative levels, suggesting that the combination of early and Putnam flutter TobraDex spirit is safe and effective.

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