Dissertation
Dissertation > Medicine, health > Chinese Medicine > TCM Pico > Modern medicine, dermatology,sexually transmitted diseases

Psoriasis vulgaris in different stages and card Hou T lymphocyte subsets

Author LiLingLing
Tutor ZuoXing
School Beijing University of Traditional Chinese Medicine
Course Surgery of Chinese Medicine
Keywords psoriasis vulgaris immune function T-lymphocyte subsets treatment of traditional Chinese medicine syndrome differentiation
CLC R275.9
Type Master's thesis
Year 2011
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Psoriasis is a kind of chronic inflammatory skin disease featured with erythema and scaling, a common disease and frequently-occurring disease in the dermatological diseases. The etiology and pathogenesis of this disease is complex, it’s mainly appeared in he young adults, the erythema will be in whole body accompanied by a large number of scaling, itching, seriously affecting the patient’s health and quality of life, bringing serious harm and heavy burden to family and social medical insurance. Therefore, it has been one of the key diseases studied and controlled in the dermatological field at home and abroad, meanwhile, because this disease is difficult to treat and easy to relapse, it is one of the key problems studied in the medical field, too.This paper includes two parts:literature review and clinical studies.Literature review has two articles in all. The first one is summarized the understanding and treatment method to psoriasis in the ancient and modern traditional Chinese medicine, as well as the progresses in the experimental research of using traditional Chinese medicine to treat the psoriasis. It is primarily explained the advancement and advantages of using traditional Chinese medicine to treat the psoriasis. The second one is summarized the progresses of immune research for psoriasis, to explore the pathogenesis of psoriasis from T cell activation, differentiation, and the interactions between each immune factor and other immune indicators.Clinical study is designed in according to the specific standards of "Guidance principle of clinical study on using new drug of traditional Chinese medicine to treat psoriasis "in "Guidance principle of clinical study on new drug of traditional Chinese medicine". Objectives:To observe the differences in the expressions of T lymphocyte subsets in the peripheral blood between the patients of psoriasis vulgaris in active stage, restoring stage, healed stage and the normal people; to observe the differences in the expressions of T lymphocyte subsets in the peripheral blood in the blood-heat syndrome, blood stasis syndrome, blood dryness syndrome of syndrome differentiation of traditional Chinese medicine for psoriasis vulgaris. Methods:the 64 patients of psoriasis vulgaris treated in the Dermatology department of Dongzhimen Hospital are the subjects of this study, of which 32 patients in the active stage who have not been treated are set as the pre-treatment group, the 32 patients in the restoring stage, and healed stage who have been treated are set as the post-treatment group,64 patients are divided into three syndromes based on the syndrome differentiation of traditional Chinese medicine, the expression levels of T lymphocyte subsets in the peripheral blood of the 64 patients with psoriasis vulgaris in different stages and syndromes are detected by the flow cytometry, and the results are conducted the statistical analysis. Results:①the CD4+ T cells in peripheral blood of patients with psoriasis vulgaris in the active stage are obviously lower than these of patients in the restoring and healed stage as well as the normal healthy value, (p= 0.00<0.01); the CD8+T cells in peripheral blood of patients with psoriasis vulgaris in the restoring and healed stage are obviously lower than these of patients in the active stage and the normal healthy value, (p= 0.00<0.01), CD4/CD8 are significantly higher than these of patients in the active stage and the normal healthy value, (p= 0.00 <0.01).②CD4+T cells have significant differences in the three groups (P= 0.00≤0.01), the trend is that the blood-heat syndrome< blood stasis syndrome < blood dryness syndrome; there is no significant difference between the blood stasis syndrome and the normal value; For CD8+ T cells, there is no significant difference between the blood-heat syndrome and the normal value, but significantly higher than these of blood stasis syndrome and blood dryness syndrome (P<0.01), and there is no significant difference between the latter two. For CD4/CD8, the blood-heat syndrome is significantly lower than these of blood stasis syndrome and blood dryness syndrome (P<0.01), and that of blood-heat syndrome is significantly lower than normal value, while these of blood stasis syndrome and blood dryness syndrome are significantly higher than the normal value (P<0.01). Conclusions:The patients with psoriasis vulgaris have the immune dysfunction, the changes of CD4+ T and CD8+ T levels are closely related with the progress and relief of disease, and the syndrome differentiations of traditional Chinese medicine; the immune states of patients with psoriasis have certain relevance with the syndromes of traditional Chinese medicine.

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