Serum Levels of Insulin Like Growth Factor-1 and Cardiovascular Remodeling in Patients with Hypertension
|School||Dalian Medical University|
|Course||Department of Cardiology|
|Keywords||hypertension cardiovascular remodeling insulin-like growth factor-1 left ventricular mass index carotid intima-media thickness|
Objective: With the social development and improvement of people’s living standards, incidence of hypertension has increased year by year. Hypertensive patients often suffer from cardiovascular and cerebrovascular disease caused by cardiac and vascular remodeling. Numerous studies now show that the occurrence of cardiac and vascular remodeling depends on many factors including hemodynamic changes, neuroendocrine factors and many cytokines, and so on. Recent studies indicated that insulin-like growth factor– 1(IGF-1) may involve in the occurrence and development of hypertension. This study is to investigate the association between serum IGF-1 levels and cardiovascular remodeling in patients with essential hypertensionMethods: The study population consisted of 89 people including 67 patients with hypertension (16 cases of grade 1, 18 cases of grade 2 ,33 cases of grade 3)and 21 normal people as control group. According to carotid intima-media thickness(IMT), hypertensive patients were divided into 3 groups: intima-media thickness (IMT) normal group (IMT <0.9mm,n=17) , IMT thickening group (IMT0.9-1.2mm, n=19) and atherosclerotic plaque group (IMT≥1.2mm, n=31). The baseline clinical data were collected including age, sex, smoking history, fasting blood glucose (FPG), triglyceride (TG), serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C),body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP) . Cardiac structure and carotid artery intima-media thickness (IMT) were measured by Color Doppler ultrasound. Carotid intima/diameter ratio(IMT/D) and left ventricular mass index(LVMI) were calculated.Results:1. Serum level of IGF-1 in Hypertension group was significantly higher than that in normal control.group( P <0.01). IMT and LVMI in hypertension group were higher than those in control group.2. With the blood pressure increasing ,serum level of IGF-1、LVMI、IMT/D、IMT in hypertension group were also increasing: IGF-1 in grade 3 was higher than that in grade 2 and grade1 (P <0.05). IGF-1 level in grade 2 was higher than that in grade 1(P <0.05). IMT and IMT/D in grade 3 were greater than those of grade 2.3. Serum level of IGF-1 was higher in the patients with carotid plaque than that in thickening group and normal group . (P < 0.05) 4. Correlation analysis showed that Serum level of IGF-1 positively relatede with LVMI, IMT. (P <0.001). The influence factors of IMT multiple linear regression analysis showed that IGF - 1 and SBP were the main factors of IMT.Conclusion:1. Serum level of IGF-1 in patients with essential hypertension significantly increased.2. Serum IGF-1 level was positive correlation with LVMI, IMT in patients with hypertension3. IGF-1 may involve in the cardiovascular remodeling in hypertensive people.