Dissertation
Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Arrhythmia > Atrial fibrillation and atrial flutter

The Effects of Telmisartan on Essential Hypertension with Paroxysmal Atrial Fibrillation

Author ZhangXiaoYang
Tutor ZhangXiangYang
School Xinjiang Medical University
Course Internal Medicine
Keywords telmisartan amlodipine hypertension paroxysmal atrial fibrillation hs- CRP
CLC R541.75
Type Master's thesis
Year 2011
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Objective: To study the effects of telmisartan on essential hypertension with paroxysmal atrial fibrillation. Methods: 68 cases of essential hypertension with paroxysmal atrial fibrillation were randomly divided into treatment group (telmisartan group, 34 patients) and the control group (amlodipine group, 34 patients) . All patients were took orally aspirin enteric-coated tablets of and other conventional anti-platelet drugs for 12 months. Follow-up time was once every 4 weeks. The patient’s heart rate, blood pressure, drug adverse reactions, the frequency and duration of atrial fibrillation recurrence were recorded. Electrocardiogram was done once every three months. The serum high-sensitivity C reactive protein (hs-CRP) level was measured once every six months. Echocardiography was finished by the end of the study. Results: 33 patients in the control group and 31 patients in treatment group have finished the follow-up.There was no signifficant difference in the age, sex, blood pressure, and heart rate of patients before and after treatment between two groups( P> 0.05). The level of serum hs-CRP(mol/L), left atrial diameter(cm), Pmax(ms)and P wave dispersion(ms)of patients , in the control group before treatment, respectively.There was no significant difference between two groups( P> 0.05).Compared with the control group , The level of serum hs-CRP(P <0.001), left atrial diameter(P <0.001), Pmax(P <0.001)and Pd(P <0.001)of patients were significantly reduced after treatment.The rate of atrial fibrillation recurrence were 36.67% and 68.75%, respectively.There were significant difference after treatment between two groups(χ~2 = 6.402, P <0.05). Conclusion: AngiotensinⅡ(AngⅡ) receptor antagonist telmisartan can decrease significantly the blood pressure, left atrial diameter, the Pmax, P wave dispersion, the serum hs- CRP levels and the recurrence rate of the patients of essential hypertention with paroxysmal atrial fibrillation.

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