The Clinical Study of ω-3 Polyunsaturated Fatty Acids in Severe Brain Injury Complicated by Lung Infection
|School||Anhui Medical University,|
|Keywords||severe brain injury lung infection ω-3 polyunsaturated fatty acids|
Objective : To observeω-3 polyunsaturated fatty acids in severe brain injury complicated by lung infection therapy effect.Methods:56 cases of severe brain injury in patients with pulmonary infection were randomly divided into control group (A) and Ewing group (B). Before division, all the patients were given the relevant examination and treatments such as antibiotics, phlegm,dehydration reducing intracranial pressure, protecting brain cells, regulating water and electrolyte acid-base balance, nutritional support, as well as endotracheal intubation, ventilator application and post-tracheotomy. Both groups were given energy supplement 25-30kcal/kg/d, but in Ewing group (B), some of the heat were provided by the fat emulsion ofω-3 fatty acids. On the 0th, 2nd, 4th and 7th day patients’maximum day temperature, respiratory rate, heart rate, white blood cell (WBC), C-reactive protein (CRP), lymphocyte subsets classification and oxygenation index were monitored, lavage fluid were examined to test TNF-α, IL-6 and IL-10, and finally prognosis, ICU stay time, ventilation time and an average cost of the two groups of patients during ICU stay time were recorded.Results:the control group and Ewing group with positive anti-infection treatments are getting better. Clinical indicators and monitoring of cytokines in bronchoalveolar lavage fluid of Ewing group and the control group on the second day were not statistically significant (p> 0.05). The vital signs (temperature, heart rate, respiration) and white blood cells of the two groups of patients showed downward trend over time, while the oxygenation index showed an upward trend over time, which is more significant for Ewing group on the 4th and 7th day compared with the control group, and the difference was statistically significant (p <0.05, p <0.01). In terms of expression level of the pro-inflammatory cytokines TNF-αin lavage fluid in inflammatory factors of the two groups of patients, Ewing group was lower than the control group on the 4th and 7th day, with the difference statistically significant (p <0.05, p < 0.01). In terms of the expression levels of IL-6 in lavage fluid on the 7th day , Ewing group was lower than the control group, with the difference statistically significant (p <0.01). The expression level of IL-10 in the lavage fluid were not statistically significant (p> 0.05). As to CRP levels on the 2nd, 4th, 7th day, Ewing group was lower than the control group, with the difference statistically significant (p <0.01). As to CD4/CD8 ratios on the 2nd, 4th, 7th day, Ewing group was higher, with the difference statistically significant (p<0.01). After the 7-day observation in the prognosis outcome, the two groups showed no significant differences, not statistically significant (p> 0.05), However, in the average ventilator time, ICU length of stay and cost, the two groups have significant differences, with statistical significance(p <0.05).Conclusion:ω-3 polyunsaturated fatty acids can improve immune status, enhance immunity, reduce inflammation on patients with the severe brain injury complicated by lung infection and have a protective effect.on the lung.