Dissertation
Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)

S100A12 in Coronary Atherosclerotic Heart Disease Expression and Significance

Author GuoZuoZuo
Tutor CuiLianQun
School Shandong University
Course Internal Medicine
Keywords Coronary heart disease S100A12 high-sensitivity C-reactive protein inflammatory cytokines
CLC R541.4
Type Master's thesis
Year 2011
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[Background]Coronary atherosclerosis in coronary heart disease is based on the hardening of coronary artery stenosis occlusion thrombosis,and result in varying degrees of myocardial ischemia.. Now it is the major cause of the death in heart disease and is the world’s most common heart disease. Currently atherosclerotic coronary heart disease’s pathogenesis remains unknown. Now it is considered that a variety of risk factors cause coronary artery endothelial cell to be injuried.Chronic inflammatory reaction result fibrosis. Inflammatory mediators of atherosclerosis are involved in all process, and a variety of inflammatory cytokines are involved in inflammation process.In recent years the calcium-binding protein S100A12 which promote the inflammatory response has been discovered to regulate monocyte migration, and to induce the expression of macrophage release of inflammatory cytokines. That leads and increases the formation of atherosclerosis. S100A12’s levels were higher in patients with coronary heart disease,and S100A12 has been the independent prediction marker of the coronary heart disease.[Objectives]The aim is to study the S100A12’s express in coronary atherosclerotic heart disease, and to observe the change of the different levels of patients with angina pectoris. We study the correlation between the S100A12’s level、metabolism markers and the inflammatory markers, and to analyze the correlation among the S100A12 as a new inflammatory factor、the hs-CRP commonly used inflammatory markers and other cardiovascular disease risk factors of relevance. We explore the clinical significance which the detection of plasma S100A12’s levels in patients with coronary heart disease assess the prognosis and prediction. The values based on the S100A12’s level of coronary atherosclerotic heart disease can predict the incidence. The study to explore the S100A12’s value in clinical diagnosis of coronary heart disease,and to guide clinical treatment.[Methods]All subjects were divided into control group and CHD group, coronary heart disease which was a continuous collection in the Department of Cardiology of Shandong Provincial Hospital in July 2010-September 2010.The76 hospitalized coronary heart disease patients were first performed PCI,whose average age was 62.7±8.8.51 cases were male patients and 25 cases were female patients.The CHD patients were enrolled in this study including stable angina (SA) 27, acute coronary syndrome (Acute coronary syndrome ACS) 49(including 39patients with unstable angina,10 patients with acute myocardial infarction).Control group including 17 was from the health checkup center of Shandong Provincial Hospital, including 9 male,8 female.Whose mean age was.59.3±8.4.All patients were collected clinical data and biochemical indicators of the general. After admitted to hospital, all patient were inquired detailed history and recorded with or without hypertension,coronary heart disease,diabetes,age, gender and blood pressure, gender, age. and smoking history.All of the subjects were fasted more than 10 hours before blood sampling. The next day morning fasting venous blood was collected. We measured the serum high sensitivity C-reactive protein (hs-CRP) levels by emulsion reinforced immunoturbidimetry, the serum S100A12 levels by enzyme linked immunoysorbent assay (ELISA), and measured fasting blood glucose (fasting plasma glucose, FPG), triglycerides (triglyceride, TG), lipoprotein(a),total cholesterol (total cholesterol, TC), high density lipoprotein cholesterol (high density lipoprotein-cholesterol, HDL-C), low-density lipoprotein cholesterol (low density lipoprotein-cholesterol, LDL-C).. Simultaneously measured left ventricular ejection fraction (Left ventricular ejection fraction LVEF), systolic blood pressure, diastolic blood pressure, body mass index and other related indicators. All data used SPSS 17.0 package for statistical analysis. p<0.05 was considered statistic difference, p<0.01 was considered significant statistic difference..[Results]1. The serum level of S100A12 in Patient with CHD is significantly higher than that in the control group.2. In different types of CHD patients can be observed in S100A12 levels are significantly increased. The S100A12 levels in stable angina, unstable angina and acute myocardial infarction are levels gradually increased. The serum level of S100A12 in acute myocardial infarction and in stable angina patients is higher than that of stable angina patients (P<0.05). Compared with each other, serum levels of S100A12 are statistically different in AMI group, UA group, SA group and NS group (p<0.05).3. S100A12 and hs-CRP are significantly related to the recent acute coronary heart disease events, and are significantly correlated. S100A12 associated positively and independently with hs-CRP..They can co-predict the acute coronary heart disease incidence and severity of coronary heart disease.[Conclusion]1. S100A12 is a pathogenic factor for coronary heart disease, which participated in the development of coronary heart disease, coronary artery disease extent and can be used as an independent predictor of changes in condition to support the diagnosis of coronary heart disease and predict the severity of coronary heart disease.2. S100A12, hs-CRP levels can reflect the severity of coronary artery disease. Serum S100A12 levels in patients with coronary heart disease than the normal control group. Different types of CHD patients can be observed in S100A12 levels were significantly increased. In stable angina, unstable angina and acute myocardial infarction S100A12 levels gradually increased.The serum level of S100A12 in acute myocardial infarction and in stable angina patients is higher than that of stable angina patients (P <0.05). Compared with each other, serum levels of S100A12 are statistically different in AMI group, UA group, SA group and NS group (p<0.05) 3. S100A12 and hs-CRP are significantly related to the recent acute coronary heart disease events, and are significantly correlated. S100A12 associated positively and independently with hs-CRP..They can co-predict the acute coronary heart disease incidence and severity of coronary heart disease.

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