Dissertation
Dissertation > Medicine, health > Internal Medicine > Respiratory system and chest diseases > Pulmonary disease > Other

Changes of Immunologic Function in Patients with Chronic Obstructive Pulmonary Disease and the Intervention by BCG Polysaccharides Nucleic Acid

Author WangNa
Tutor ZhangXiangYan
School Zunyi Medical College,
Course Respiration within the science
Keywords Chronic obstructive pulmonary disease Lymphocyte BCG polysaccharides nucleic acid Immunity
CLC R563.9
Type Master's thesis
Year 2011
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Objective:To study the changes of immunologic function in patients with chronic obstructive pulmonary disease (COPD) and the intervention by BCG polysaccharides nucleic acid.Methods:We selected 90 subjects with COPD and divided them into two group:COPD group of acute exacerbation (n=30), COPD group of remission (n=60). At the same time, 60 healthy subjects were chosen as control groups:healthy senile group (n=30) and 30 h-ealthy non-senile group (n=30). In addition, we allocated the COPD patients at remission stage into treatment group (n=30) and control group (n=30) randomly. COPD treatment group received BCG polysaccharides nucleic acid (0.35mg intramuscular injection, three times a week) and conventional therapy while COPD control group only received conv-entional therapy. The patients in two groups were followed up for 1 month. Lymphocyte subpopulation, NK and B lymphocyte percentages were determined before and after treatment.Results:①Compared with non-elderly healthy adults,CD3+,CD4+,CD4+/CD8+,B lymp-hocyte in healthy senile group were decreased (all P<0.05)while NK lymphocyte percent-age was increased (all P<0.05).②Compared with the healthy senile group, healthy non-senile group and COPD group of remission, COPD of acute exacerbation patients showed decrease of CD3+,CD4+,CD4+/CD8+ and B lymphocyte (all P<0.05),while NK lympho-cyte were increased(all P<0.05).③Compared with healthy senile group and healthy non-senile group, CD3+,CD4+,CD4+/CD8+,B lymphocyte in COPD group of remission were decreased(all P<0.05)while NK lymphocyte were increased(all P<0.05).④In COPD control group, there were no differences in CD3+, CD4+, CD8+, CD4+/CD8+, B lymph-ocyte and NK lymphocyte between pre and post treatment(all P>0.05).⑤After treatment with BCG polysaccharides nucleic acid CD4+, CD4+/CD8+ and B lymphocyte were significantly increased (all P<0.05), while CD8+ were decreased (all P<0.05). CD4+, CD4+/CD8+and B lymphocyte were higher in COPD treatment group after receiving BCG polysaccharides nucleic acid, than those in COPD control group pre and post treatment (P<0.05) while CD8+ were decreased(P<0.05).Conclusions:①With the growth of age, immunologic function declines in healthy people.②Abnormal immune responses can be found in COPD patients, especially during acute exacerbation.③BCG polysaccharides nucleic acid can improve immunity in patients with COPD.

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