Improvement of the Result of Autologous Fat Transplantation in Facial Recontouring Surgery by Using "Cocktail" Therapy
|School||Dalian Medical University|
|Keywords||autologous fat transplantation facial contouring gene therapy cell therapy facilitative technique|
Objective:Autologous fat transplantation (AFT) is considered to be an ideal option for facial recontouring surgery. However, poor survival rate (lower 30% in average) due to fat absorption and necrosis limits its practical use and clinical application. Although many approaches are attempting to improve AFT’s results, such as facilitative technique refining, vascularization enhancing and cell proliferation promoting. Previous studies showed limited effects on individual use. On the other hand, recent researches in animals showed that combined use of multiple approaches might yield much more significant and meaningful improvement. This study focuses on using so-called "cocktail" therapy to combined various treatments, including facilitative technique, cell therapy, gene therapy and high glucose therapy, which has not been applied jointly before in clinical practice, to investigate the potentially optimal results of AFT in facial recontouring surgery.Methods:Twenty females were recruited to participate facial autologous fat transplantation and were divided into two groups adopting cocktailed and traditional therapy respectively. Photo-images were taken at 7th and 90th day after surgery in order to calculate changes of facial volume by using photo model analysis.Results:Results showed the survival rates of facial AFT with traditional therapy ranged between 20%(within nasolabial fold)-40%(within risorius muscle) which proximate to the results of previous researches. Those with cocktailed therapy demonstrated much more higher survival rate approaching 63%(within nasolabial fold)～75%(within risorius muscle). It was concluded that cocktailed therapy combined with multiple treatments had great effect and promising potential on improving the result of autologous fat transplantation in facial recontouring surgery. However, further studies were suggested to clarify the interaction between different treatments and the optimality of combination.