An Observation of the Concentration Changes of MTX in Maternal Milk and Serum in Partial Placenta Increta
|School||Zunyi Medical College,|
|Course||Obstetrics and Gynaecology|
|Keywords||HPLC methotrexate maternal milk pharmacokinetics serum|
Objective:To explor the pharmacokinetic features of MTX in maternal milk and serum by observation its concentration changes after being injected in puerperal women with placenta increta,and for the further purpose of providing theroretical basis of reasonable time for child child feeding in clinic.Methods:After a single-dose intramuscular injection of MTX (50mg/m2) in twelve cesarean section partial placenta accrete patients which was confirmed by pathological diagnosis,Breast milk samples after intramuscular injection at the hour of 0.5,1,2,4,8,12,18,24,48 and serum samples at the hour of 12,24,48,72.Which concentrations of MTX were assayed by high performance liquid chromatography (HPLC), the pharmacokinetic parameters of milk were calculated with 3P97 program.Results:The main pharmacokinetic parameters of milk were as follows:tmax (4.92±1.37)h,Cmax (1.39±0.21)mg·L-1,t1/2ke(8.42±3.43)h. Following im administration at the 48、72 hours,MTX were not detected in milk. During 12 postparum women,5 cases were not detected in serum at the 12 hours,7 cases were detected,but there are individual differences in the concentration of relatively large fluctuations from 0.57mg/L to 23.4mg/L Following im administration in 72 hours, MTX were not detected in serum.Conclusion:After MTX inject in partial placenta accrete postparum women at the 72 hours, MTX were not detected in breast milk and serum. It recommend that after using the MTX at the 72 hours,the breast-feeding events should be relatively safe.