Dissertation
Dissertation > Medicine, health > Pharmacy > Pharmacology

The Preparation and Pharmacodynamics of Ropivacaine Gelatin Microspheres

Author ZhaoFeng
Tutor ZhangHong
School PLA Postgraduate Medical School
Course Anesthesiology
Keywords gelatin microsphere ropivacaine pharmacodynamics
CLC R96
Type Master's thesis
Year 2009
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Objective:To study the preparation and pharmacodynamics of Ropivacaine Gelatin Microspheres Method:Ropivacaine Gelatin Microspheres were prepared by emulsion-crosslinking method,and were observed by super-microscope and the diameter of microsphere was measured,the content of ropivacaine was measured by method of ultraviolet spectrophotometer.The microspheres were also implanted into rats’s sciatic nerve to study the maintainess time of analgesia.Results:The Ropivacaine Gelatin Microspheres were deep yellow powders and they were globular when observed in the super-microscope.The average diameter of the Ropivacaine Gelatin Microspheres were 28.9±9.Sum The content of ropivacaine in the microspheres is 21.4%,and the ratio of drug envelopment is 74.8%.The best ratios of ropivacaine and carriers was 1:2.5 The results of phamacodynamics in rats showed the Ropivacaine Gelatin Microspheres could prolong the time of ropivacaine to about 4 hours.Conclusion:The Ropivacaine Gelatin Microspheres is a new altered dosage form and preparing method is easy.They have good properties of drug sustain releasing.They can prolong the analgesia time of ropivacaine.

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