Efficacy and Safety Evaluation of Claritin Treatment on Children with Asthma
|School||Xinjiang Medical University|
|Keywords||Loratadine Efficacy evaluation Safety evaluation Children|
Objective : To evaluate the efficacy and safety of loratadine (claritin) treatment on childhood asthma, we can provide the reasonable drug regimens and clinical reference for the treatment of asthma. Methods: According to the Cochrane reviewer’s handbook, Trials were assessed for quality. A systematic review was made . Electronic search and hand search was applied to CENTRAL, published in the latest issue of PubMed?MEDLINE?EMBASE?Cochrance?CNKI?CBMdisc (since January 1990 to December 2010) . Results: 179 articles have been involved in the study. According to the chosen criteria, 11 randomized controlled study meet the requirement and other were excluded from the study. The qualified randomized with loratadine and 156 cases were treated with placebo. All included studies belonged to the B class according to the quality evaluation criteria. Meta analysis showed that compared to Control group, the mean difference of clinical scores, the mean difference of 4-week, 8-week follow-up FEV1, the mean difference of 8-week PEFR (peak expiratory flow rate) were all significant greater than control group. And adverse reactions such as fatigue and tachycardia, palpitation of treatment group are less than control group. Conclusion: It is safe and effective to use loratadine to treat childhood asthma with a low incidence of adverse reactions, which is worth to promote in clinical.