Dissertation
Dissertation > Medicine, health > Pediatrics > Children within the science > Department of pediatric respiratory and chest diseases

Diagnostic Value of Detection Urinary Trace Protein for Early Kidney Impairment in Infants with Mycoplasma Pneumonia

Author MaJingBin
Tutor LiuZhengJuan
School Dalian Medical University
Course Pediatrics
Keywords mycoplasma pneumoniae kidney impairment urinary micoalbuminuria children
CLC R725.6
Type Master's thesis
Year 2011
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Objective:Mycoplasma pneumoniae is one of the common pathogens of children respiratory infections. Besides causing respiratory symptoms and signs, it can still be associated with multiple systems or organs outside the lung. Particularly the kidney impairment has received more and more attention.In this paper, we explore the diagnosable significance of urinary trace protein, based on the study of part of the children admitted to our hospital, detecting for the kidney impairment infants with mycoplasma pneumoniae for early diagnosis and treatment.Methods:Ninety-six of the children admitted to our paediatric ward from March 2009 to Dec 2010 were selected randomly, among which there are 40 infants with mycoplasma pneumonia and 56 infants with other pneumonia. The urinary level of urinary micoalbuminuria andβ2-microglobulin of 40 infants with mycoplasma pneumonia and 56 infants with other pneumonia were detected. Routine urine test, renal function and other routine screening were detected at the same time. Compare the positive rate of urinary micoalbuminuria,β2-microglobulin and urine routine in patients whose renal function were normal.Results:The level of urinary micoalbuminuria andβ2-microglobulin in the infants with mycoplasma pneumoniae were higher those of infants with other pneumonia, and the differences beteen the two groups were statistically significant (P <0.05) . Mycoplasma pneumoniae infection may casue renal tubular and glomerular damage. The urinary micoalbuminuria may be one of a sensitive indicators to the early renal injury diagnosis of mycoplasma pneumoniae infants. The positive rate of urinary micoalbuminuria in infants with mycoplasma pneumoniae were 35%, while the positive rate of urinaryβ2-microglobulin of this group were 12.5%. The abnormity rates of urinary micoalbuminuria in infants with mycoplasma pneumoniae were significantly higher than those of urinaryβ2-microglobulin (P <0.05) . It suggests that early kidney damage was glomerular-based in the infants with mycoplasma pneumoniae. Ten out of 14 patients with mycoplasma pneumo-niae whose urinary micoalbuminuria were abnomal have norma urinary routinel. It suggests that these patuents kidney impairment has already occurred even if the urinary routine were negative. The positive rate of urinary micoalbuminuria in the infants with mycoplasma pneumonia were 35% without treatment, while the abnormity rates of those were 7.5% after treatment. The number of abnormal cases were less than those before treatment. Early kidney impairment caused by mycoplasma pneumoniae are mostly reversible, and can be improved with the disease recovery.Conclusion:1. The urinary micoalbuminuria may be one of a sensitive indicators to the early renal injury diagnosis of mycoplasma pneumoniae infants; 2. Early kidney damage was glomerular-based in the infants with mycoplasma pneumoniae; 3. Mycoplasma pneumoniae infection may also cause renal tubular damage.

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