Effects of Imipramine on Behavioral Sensitization of Morphine in the Chronic Mild Stress-depressed Rats
|School||Capital Normal University|
|Keywords||morphine behavioral sensitization depression imipramine|
The key study of drug dependence and addiction is exploring factors and mechanism leading to drug addiction and relapse.Clinical evidence and animal experiments have found that:addicted patients frequently show the emotion of depression,depression is a common feature of various drug addicts;some antidepressant drugs has been shown to relieve drug addiction,suggesting that there is some relationship between depression and drug addiction.But current research couldn’t elucidate whether the depression reflects preexisting traits,or the effects of exposure to the drug.The animal model prodives a better method to research the relationship of depression and drug addiction:the behavioral sensitization animal model is proverbially used in the study of drug addiction,the chronic mild stress procedure is an useful and reliable model of depression. This experiment was designed to explore the effect of imipramine on the morphine addiction after the performance of the chronic mild stress procedure.Based on the relationship between behavioral sensitization and addiction susceptibility,we investigate(1) the morphine behavioral sensitization in model rats treated with chronic mild stress;(2)The effect of imipramine on the morphine behavioral sensitization in model rats treated with chronic mild stress.Our results showed that:(1)the locomotion of depression group and imipramine-depression group were significantly higher than non-depression group after treatment with 4mg/kg morphine;(2) the locomotion of depression group was significantly higher than non-depression group in the development of behavioral sensitization,no difference was observed between imipramine-depression group and non-depression group;(3) and in the expression period,the locomotion of depression group was significantly higher than non-depression group,no difference was observed between imipramine-depression group and non-depression group.Conclusions:(1)the locomotion of depression group were significantly higher than non-depression group after treatment with 4mg/kg morphine;Imipramine inhibited this effect.(2) there is relationship between depression and addiction susceptibility,and the relapse in morphine addiction may be influenced by the emotion of depression.(3) Imipramine has an inhibition on behavioral sensitization of morphine in the chronic mild stress-depressed rats.The effect of the chronic mild stress-depression on morphine behavioral sensitization could be inhibited by imipramine,suggesting that mild stress-depression is one of factors leading to drug addiction and relapse.Imipramine could cure drug addiction and relapse.